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Eosinophilic Granulated Cells Comprising a Tumor in a Fischer Rat

Biosafety Research Center, Foods, Drugs and Pesticides (An-Pyo Center), Shizuoka, Japan

Masayo Hosoi

Biosafety Research Center, Foods, Drugs and Pesticides (An-Pyo Center), Shizuoka, Japan

Shinji Yamamoto

Biosafety Research Center, Foods, Drugs and Pesticides (An-Pyo Center), Shizuoka, Japan

Shin-Ichi Mikami

Biosafety Research Center, Foods, Drugs and Pesticides (An-Pyo Center), Shizuoka, Japan

Seiki Yamakawa

Biosafety Research Center, Foods, Drugs and Pesticides (An-Pyo Center), Shizuoka, Japan

Hijiri Iwata

Biosafety Research Center, Foods, Drugs and Pesticides (An-Pyo Center), Shizuoka, Japan

Makoto Enomoto

Biosafety Research Center, Foods, Drugs and Pesticides (An-Pyo Center), Shizuoka, Japan

A systemic tumor developed in multiple organs, including spleen, bone marrow, lymph nodes, liver, ovaries, and thoracic and lumbar vertebrae, of a female F344Du/Crj rat. The tumor was composed of round to indented mononuclear cells containing abundant large eosinophilic granules in the cytoplasm. The peripheral blood smear revealed that the large granules in the cytoplasm of the tumor cells were stained basophilic with Giemsa, suggesting a basophil or mast cell origin. However, these granules did not show metachromasia with toluidine blue and were stained blue to dark blue with phosphotungstic acid hematoxylin. Cellular morphology and characteristics in the specific stains of tumor cells suggested the development of a tumor of globule leukocytes in a F344Du/Crj rat.

Key Words: Globule leukocyte • mast cell tumor • LGL leukemia

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Toxicologic Pathology, Vol. 27, No. 2, 233-236 (1999)
DOI: 10.1177/019262339902700210


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Miyajima, R. Articles by Enomoto, M. Search for Related Content PubMed PubMed Citation Articles by Miyajima, R. Articles by Enomoto, M. Pubmed/NCBI databases Medline Plus Health Information Cancer Social Bookmarking                         What's this?