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Toxicologic Pathology
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Commentary

Marriage of a Medium-Term Liver Model to Surrogate Markers—A Practical Approach for Risk and Benefit Assessment

Malcolm A. Moore

Division of Chemotherapy, National Cancer Research Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104, Japan

Hiroyuki Tsuda

Division of Chemotherapy, National Cancer Research Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104, Japan

Seiko Tamano

First Department of Pathology

Akihiro Hagiwara

First Department of Pathology

Katsumi Imaida

First Department of Pathology

Tomoyuki Shirai

First Department of Pathology

Nobuyuki Ito

President, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467, Japan

The need for a reliable medium-term alternative to traditional long-term rodent test protocols for carcinogen risk assessment is pressing given the immense variety of compounds being developed for introduction into the human environment. The established lack of a complete correlation between mutagenicity and carcinogenicity means that recourse must be made to an in vivo model. Optimally, this model should be able to detect not only complete carcinogenic or promoting potential but also any ability to inhibit neoplasia. In order to be effective, it must take into account the available detailed knowledge on mechanisms of action of carcinogens and modulating agents. The Ito model, for which a uniquely comprehensive set of background data has already been accumulated, has a solid scientific basis; this model utilizes quantitative data for glutathione S transferase-positive foci as the preneoplasia-based surrogate end point (PSE). A very practical candidate for routine application, its predictive power, its flexibility, and its capacity to incorporate a range of mechanism-based surrogate end points (MSEs) provide a powerful tool for attainment of the twin goals of detecting carcinogenic agents and identifying promising chemopreventors.

References

  • Ashby J., Brady A., Elcombe CR, Elliott BM, Ishmael J., Odun J., Tugwood JD, Kettle S., and Purchase Ifh (1994). Mechanisticallybased human hazard assessment of peroxisome proliferator-induced hepatocarcinogenesis. Hum. Exp. Toxicol. 2: S111-S117.
  • Bannasch P. (1986). Preneoplastic lesions as end points in carcinogenicity testing. I. Hepatic preneoplasia. Carcinogenesis 7: 689-695.[Free Full Text]
  • Bruning PF, Bonfrer JM, van Noord Pah, Hart Aam, de Jong-Backer M., and Nooijen WJ (1992). Insulin resistance and breast-cancer risk. Int. J. Cancer 52: 511-516.[Web of Science][Medline] [Order article via Infotrieve]
  • Butterworth BE, Conolly RB, Morgan KT (1995). A strategy for establishing mode of action of chemical carcinogens as a guide for approaches to risk assessments. Cancer Lett. 93: 129-146.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Chang W-CL, Chapkin RS, and Lupton JR (1997). Predictive value of proliferation, differentiation and apoptosis as intermediate markers for colon tumorigenesis. Carcinogenesis 18: 721-730.[Abstract/Free Full Text]
  • Chiara M., Sesca E., Binasco V., and Tessitore L. (1996). Fasting/ refeeding enhances the development of mammary tumors induced by methylnitrosourea in the rat. Boll. Soc. Ital. Biol. Sper. 72: 211-216.[Medline] [Order article via Infotrieve]
  • Cohen S. and Ellwein LB (1990). Cell proliferation in carcinogenesis. Science 249: 1007-1011.[Abstract/Free Full Text]
  • Cohen S. and Ellwein LB (1991). Genetic errors, cell proliferation, and carcinogenesis. Cancer Res. 51: 6493-6496.[Free Full Text]
  • Doll R. (1988). Epidemiology and the prevention of cancer: Some recent developments. J. Cancer Res. Clin. Oncol. 114: 447-458.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Dreher D. and Junod AF (1996). Role of oxygen free radicals in cancer development. Eur. J. Cancer 32: 30-38.[Medline] [Order article via Infotrieve]
  • Einspahr JG, Alberts DS, Gapstur SM, Bostick RM, Emerson SS, and Gerner EW (1997). Surrogate end-point markers as measures of colon cancer risk and their use in cancer chemoprevention trials. Cancer Epidemiol. Biomarkers Prev. 6: 37-48.[Abstract/Free Full Text]
  • Farber E. (1995). Cell proliferation as a major risk factor for cancer: A concept of doubtful validity. Cancer Res. 55: 3759-3762.[Free Full Text]
  • Futakuchi M., Lijinsky W., Hasegawa R., Hirose M., Ito N., and Shirai T. (1996). Effects of low dose mixtures of four N-nitroso compounds on hepatic foci development in the rat. Cancer Lett. 104: 37-41.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Giovannucci E. (1995). Insulin and colon cancer. Cancer Causes Control 6: 164-179.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Hagiwara A., Tanaka H., Imaida K., Tamano S., Fukushima S., and Ito N. (1993). Correlation between medium-term multi-organ carcinogenesis bioassay data and long-term observation results in rats. Jpn. J. Cancer Res. 84: 237-245.[CrossRef][Web of Science]
  • Hasegawa R., Yoshimura I., Imaida K., Ito N., and Shirai T. (1996). Analysis of synergism in hepatocarcinogenesis based on preneoplastic foci induction by 10 heterocyclic amines in the rat. Jpn. J. Cancer Res. 87: 1125-1133.[CrossRef][Web of Science]
  • Hikita H., Vaughan J., Pitot HC (1997). The effect of two periods of short-term fasting during the promotion stage of hepatocarcinogenesis in rats: The role of apoptosis and cell proliferation. Carcinogenesis 18: 159-166.[Abstract/Free Full Text]
  • Huff JE (1992). Chemical toxicity and chemical carcinogenesis. Is there a causal connection? A comparative evaluation of 1500 experiments. In: Mechanisms of Carcinogenesis in Risk Identification. H Vainio, PN Magee, DB McGregor, and AJ McMichael (eds). IARC, Lyon, New York, pp. 437-475.
  • International Agency for Research on Cancer (1972-1996). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vols. 1-66. IARC. Lyon.
  • Ito N., Hasegawa R., Imaida K., Hirose M. and Shirai T. (1996). Medium-term liver and multi-organ carcinogenesis bioassays for carcinogen and chemopreventive agents. Exp. Toxicol. Pathol. 48: 113-119.
  • Ito N., Hasegawa R., Imaida K., Hirose M., Shirai T., Tamano S., and Hagiwara A. (1997). Medium-term rat liver bioassay for rapid detection of hepatocarcinogenic substances. Toxicol. Pathol. 10: 1-11.[Medline] [Order article via Infotrieve]
  • Lagopoulos L., Sunahara GI, Wirzner H., Fliesen T., and Stalder R. (1991). The correlation of body growth with diethylnitrosamineinduced hepatocarcinogenesis in relation to serum insulin and somatomedin-C. Carcinogenesis 12: 211-215.[Abstract/Free Full Text]
  • McKeown-Eyssen G. (1994). Epidemiology of colorectal cancer revisited: Are serum triglycerides and/or plasma glucose associated with risk? Cancer Epidemiol. Biomarkers Prev. 3: 687-695.[Abstract]
  • Metzger C., Mayer D., Hoffmann H., Bocker T., Hobe G., Benner A., and Bannasch P. (1995). Sequential appearance and ultrastructure of amphophilic foci, adenomas and carcinomas in the liver of male and female rats treated with dehydroepiandrosterone (DHEA). Toxicol. Pathol. 23: 591-605.[Abstract/Free Full Text]
  • Moore MA, Nakagawa K., Satoh K., Ishikawa T., and Sato K. (1987). Single GST-P positive liver cells—Putative initiated hepatocytes. Carcinogenesis 8: 483-486.[Abstract/Free Full Text]
  • Ogiso T., Tatematsu M., Tamano S., Tsuda H., and Ito N. (1985). Comparative effects of carcinogens on the induction of placental glutathione S-transferase-positive liver nodules in a short-term assay and of hepatocellular carcinomas in a long-term assay. Toxicol. Pathol. 13: 257-265.[Medline] [Order article via Infotrieve]
  • Pisani P., Parkin DM, Munoz N., and Ferlay J. (1997). Cancer and infection: Estimates of the attributable fraction in 1990. Cancer Epidemiol. Biomarkers Prev. 6: 387-400.[Abstract]
  • Potten CS, Li YQ, O'Connor PJ, and Winton DJ (1992). A possible explanation for the differential cancer incidence in the intestine, based on the distribution of toxic effects of carcinogens in the murine large bowel. Carcinogenesis 13: 2305-2312.[Abstract/Free Full Text]
  • Rao MS, Tatematsu M., SubbArao V., Ito N., and Reddy JK (1986). Analysis of peroxisome proliferator-induced preneoplastic and neoplastic lesions of the rat liver for placental form of glutathione S-transferase and g-glutamyl transpeptidase. Cancer Res. 46: 5287-5290.[Abstract/Free Full Text]
  • Satoh K., Hatayama I., Tateoka N., Tamai K., Shimizu T., Tatematsu M., Ito N., and Sato K. ( 1989). Transient induction of single GST-P positive hepatocytes by DEN. Carcinogenesis 10: 2107-2111.[Abstract/Free Full Text]
  • Schatzkin A., Freedman LS, Dorgan J., McShane LM, Schiffman MH, and Dawsey SM (1996). Surrogate end points in cancer research: A critique. Cancer Epidemiol. Biomarkers Prev. 5: 947-953.[Abstract]
  • Solt DB and Farber E. (1976). New principle for the analysis of chemical carcinogenesis. Nature 263: 702-703.
  • Stinchcombe S., Buchmann A., Bock KW, and Schwarz M. (1995). Inhibition of apoptosis during 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated tumour promotion in rat liver. Carcinogenesis 16: 1271-1275.[Abstract/Free Full Text]
  • Tagliaferro AR, Ronan AM, Meeker LD, Thompson HJ, and Scott AL (1997). Cyclic food restriction, insulin and mammary cell proliferation in the rat. Carcinogenesis 18: 2271-2276.[Abstract/Free Full Text]
  • Ward JM, Tsuda H., Tatematsu M., Hagiwara A., and Ito N. (1989). Hepatotoxicity of agents that enhance formation of focal hepatocellular proliferative lesions (putative preneoplastic foci) in a rapid rat liver bioassay. Fund. Appl. Toxicol. 12: 163-171.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Ward JM, Uno H., Kurata Y., Weghorst CM, and Jang J-J. (1993). Cell proliferation not associated with carcinogenesis in rodents and humans. Environ. Health Perspect. 101: S124-S136.
  • Weber E., Moore MA, and Bannasch P. (1988). Enzyme histochemical and morphological phenotype of amphophilic foci and amphophilic/tigroid cell neoplastic nodules in rat liver after combined treatment with dehydroepiandrosterone and N-nitrosomorpholine. Carcinogenesis 9: 1049-1054.[Abstract/Free Full Text]

Toxicologic Pathology, Vol. 27, No. 2, 237-242 (1999)
DOI: 10.1177/019262339902700211
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