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Review Article: "Mesenchymal Tumor" or "Decidual-Like Reaction"?
Eberhard Karbe
Consultant for Pathology and Toxicology, Langendorfer Strasse 17, 42489 Wuelfrath, Germany, eberhard.karbe{at}t-online.de.
For more than 40 yr, an unusual urinary bladder lesion has been known to occur in certain strains of mice, but no consensus has been obtained regarding its etiology, pathogenesis, biology, or classification. The lesion was first assumed to be epithelial and non-neoplastic, then it was called a smooth muscle cell tumor or leiomyosarcoma because of ultrastructural characteristics for smooth muscle cells. Later, the nonspecific term "mesenchymal tumor" was introduced due to histomorphologic differences from all smooth muscle tumors known. Recently, a proposal was made to name it "decidual-like reaction" because of the histomorphologic similarity to the rare spontaneous decidual reaction in the uterus of aging mice. Both lesions are characterized by spindle and large pleomorphic epithelioid cells with large bizarre nuclei; these characteristics mimic anaplasia of malignant tumors and led pathologists to assume a neoplastic nature. The decidual hypothesis is supported by the regular presence of nuclear progesterone receptors, the occasional occurrence of eosinophilic cytoplasmic granules, the rare finding of cells morphologically resembling granulated metrial gland cells (all also observed in the uterine decidual reaction), and the reproducibility through long-term feeding of combinations of estrogens and progestogens. It appears that the new decidual hypothesis can explain many detailed facets of the lesion, with the exception of the reported smooth muscle cell characteristics. The controversy of "mesenchymal tumor versus decidual-like reaction" should be resolved soon, not only as a scientific issue, but also because of consequences for risk assessment.
Key Words: Urinary bladder • mouse • vegetative lesion • leiomyosarcoma • progesterone receptor • decidualization • granulated metrial gland cell
References
- Abrahamsohn PA and Zorn Tmt (1993). Implantation and decidualization in rodents. J. Exp. Zool. 226: 603-628.
- Amanuma T., Cathew P., Davis BJ (1998). Comparison of Immunohistochemical Markers between Surgically-Induced and Spontaneous Deciduoma in Rats and Mice. Poster at the 17th International Symposium of the Society of Toxicologic Pathology, Vancouver, British Columbia.
- Bonser GM and Jull JW (1956). The histological changes in the mouse bladder following surgical implantation of paraffin wax pellets containing various chemicals. J. Pathol. Bacteriol. 72: 489-495.[CrossRef][Web of Science]
- Boorman GA, Wood M., and Fukushima S. (1994). Tumours of the urinary bladder. In: Pathology of Tumours in Laboratory Animals, Vol. 2, Tumours of the Mouse, 2nd ed., V Turusov and U Mohr (eds). International Agency for Research on Cancer, Lyon, France, pp. 383-406.
- Butler WH, Cohen SH, and Squire RA (1997). Mesenchymal tumors of the mouse urinary bladder with vascular and smooth muscle differentiation. Toxicol. Pathol. 25: 268-274.[Abstract/Free Full Text]
- Chandra M. and Frith CH (1991). Spontaneously occurring leiomyosarcomas of the mouse urinary bladder. Toxicol. Pathol. 19: 164-167.[Web of Science][Medline]
[Order article via Infotrieve]
- DeFeo VJ (1967). Decidualization. In: Cellular Biology of the Uterus, RM Wynn (ed). Appleton-Century-Crofts, New York, pp. 191-290.
- Elcock L., Stuart BP, Mueller RE, and Hoss HE (1987). Deciduoma, uterus, rat. In: Monographs on Pathology of Laboratory Animals, Genital System, TC Jones, U Mohr, and RD Hunt (eds). Springer, Berlin, pp. 140-146.
- Ghadially FN (1988). Ultrastructural Pathology of the Cell and Matrix. Butterworths, London, pp. 876-878.
- Gopinath C. (1992). Susceptibility of the uterus to toxic substances. In: Pathobiology of the Aging Rat, Vol. 1, U Mohr, DL Dungworth, and CC Capen (eds). ILSI Press, Washington, D.C., pp. 389-394.
- Gopinath C., Prentice DE, and Lewis DJ (1987). Atlas of Experimental Toxicological Pathology, Vol. 13. MTP Press, Boston.
- Halliwell WH (1998). Submucosal mesenchymal tumors of the mouse urinary bladder. Toxicol. Pathol. 26: 128-136.[Abstract/Free Full Text]
- Jacobs JB, Cohen SM, Arai M., Freidell GH, Bulay O., and Urman HK (1976). Chemically induced smooth muscle tumors of the mouse urinary bladder. Cancer Res. 36: 2396-2398.[Abstract/Free Full Text]
- Jones Cjp, Aplin JO, Mulholland J., and Glasser SR (1993). Patterns of sialylation in differentiating rat decidual cells as revealed by lectin histochemistry. J. Reprod. Fertil. 99: 635-645.[Abstract/Free Full Text]
- Karbe E. (1997). The Development of "Mesenchymal Lesions" in the Mouse Urinary Bladder. Poster at the 16th International Symposium of the Society Toxicologic Pathology, Beaver Creek, Colorado.
- Karbe E., Hartmann, E., Durchfeld-Meyer B., Geiss V., Wadsworth P., George C., Harleman J., and Schaetti P. (1998). Is the "Mesenchymal Lesion" of the Mouse Urinary Bladder a Type of Decidual Reaction? Poster at the 17th International Symposium of the Society Toxicologic Pathology, Vancouver, British Columbia.
- Karbe E., Hartmann E., George C., Wadsworth P., Harleman J., and Geiss V. (1998). Similarities between the uterine decidual reaction and the "mesenchymal lesion" of the urinary bladder in aging mice. Exp. Toxicol. Pathol. 50: 330-340.
- Leiniger JR and Jokinen MP (1990). Oviduct, uterus, and vagina. In: Pathology of the Fischer Rat, GA Boorman, SL Eustis, MR Elwell, CA Montgomery, Jr, and WF MacKenzie (eds). Academic Press, San Diego, pp. 443-459.
- Leiser R., Schäfer A., Mootz U., Krebs C., and Beier HM (1997). Implantation as beginning of the placentation process in the rabbit: Vascular studies at a suitable model shown by light versus scanning electron microscopy. In: Microscopy of Reproduction and Development: A Dynamic Approach, PM Motta (ed). Antonio Delfino Editore, Rome, pp. 251-259.
- Maekawa A. and Maita K. (1996). Changes in the uterus and vagina. In: Pathobiology of the Aging Mouse, Vol. 1, U Mohr, DL Dungworth, CC Capen, WW Carlton, JP Sunderg, and JM Ward (eds). ILSI Press, Washington, D.C., pp. 469-480.
- McConnell RF (1989). General observations on the effects of sex steroids in rodents with emphasis on long-term oral contraceptive studies. In: Safety Requirements for Contraceptive Steroids, F Michael (ed). Cambridge University Press, New York, pp. 211-229.
- Peel S. (1989). Granulated metrial gland cells. Adv. Anat. Embryol. Cell Biol. 115: 1-112.
- Roe Fjc (1964). An illustrated classification of the proliferative and neoplastic changes in mouse bladder epithelium in response to prolonged irritation. Br. J. Urol. 36: 238-253.[Medline]
[Order article via Infotrieve]
- Sananès N., Baulieu EE, and Le Goascogne C. (1981). A role for prostaglandins in decidualization of the rat uterus. J. Endocrinol. 110: 25-33.
- Urman HK, Bulay O., Clayton DB, and Shubik P. (1975). Carcinogenic effects of Niridazole. Cancer Lett. 1: 69-74.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Wood M. and Bonser GM (1979). Tumours of the urinary bladder. In: Pathology of Tumours in Laboratory Animals, Vol. 2, Tumours of the Mouse, VS Turusov (ed). International Agency for Research on Cancer, Lyon, France, pp. 301-324.
- Zhang X. and Croy BA (1996). Maintenance of decidual cell reaction by androgens in the mouse. Biol. Reprod. 55: 519-524.[Abstract]
- Zook BC (1987). Deciduosarcomas in rabbits induced by the combination of estrogen and progestin. In: Monographs on Pathology of Laboratory Animals, TC Jones, U Mohr, and RD Hunt (eds). Springer, Berlin, pp. 72-78.
- Zook BC, Spiro I., and Hertz R. (1987). Malignant neoplasms of decidual origin (deciduosarcomas) induced by estrogen-progestin-releasing intravaginal devices in rabbits. Am. J. Pathol. 128: 315-327.[Abstract]
Toxicologic Pathology, Vol. 27, No. 3,
354-362 (1999)
DOI: 10.1177/019262339902700312
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