|
Sign In to gain access to subscriptions and/or personal tools.
|
Case Report: Spontaneous Hemangiosarcoma in the Pancreas of a Fischer Rat
Osamu Katsuta
Mitsubishi Chemical Safety Institute Ltd., 14 Sunayama, Hasaki-machi, Kashima-gun, Ibaraki-ken 314-0255, Japan
Takuya Doi
Mitsubishi Chemical Safety Institute Ltd., 14 Sunayama, Hasaki-machi, Kashima-gun, Ibaraki-ken 314-0255, Japan
Yoshimasa Okazaki
Mitsubishi Chemical Safety Institute Ltd., 14 Sunayama, Hasaki-machi, Kashima-gun, Ibaraki-ken 314-0255, Japan
Yumi Wako
Mitsubishi Chemical Safety Institute Ltd., 14 Sunayama, Hasaki-machi, Kashima-gun, Ibaraki-ken 314-0255, Japan
Minoru Tsuchitani
Mitsubishi Chemical Safety Institute Ltd., 14 Sunayama, Hasaki-machi, Kashima-gun, Ibaraki-ken 314-0255, Japan
Spontaneous hemangioma or hemangiosarcoma is sometimes found in the viscera and soft tissue of rats and mice. However, there is no report of the tumor occurring in the pancreas of rats. We report a pancreatic hemangiosarcoma in a 109-wk-old, male Fischer 344 rat, which was used in the control group of a carcinogenicity study. The tumor destroyed and compressed the normal pancreatic tissue and displayed a high density in terms of the numerous capillaries and strands of endothelial tumor cells. A reticulin stain revealed a dense network formation. The frequency of proliferating cell nuclear antigen-positive staining showed active proliferation of the tumor cells. Immunohistochemically, some of the tumor cells stained positive with factor VIII-related antigen, and ultrastructurally, Weibel-Palade bodies were rarely observed in the cytoplasm of the tumor cell. From these findings, the tumor was diagnosed as a hemangiosarcoma that occurred naturally in the pancreas.
Key Words: Spontaneous tumor • pancreas • hemangiosarcoma • Fischer rat
References
- Carstens Phb and Schrodt GR (1974). Ultrastructure of sclerosing hemangioma. Am. J. Pathol. 77: 377-386.[Web of Science][Medline]
[Order article via Infotrieve]
- Cohen SM, Ertúrk E., Von Esch AM, Crovetti AJ, and Bryan GT (1975). Carcinogenicity of 5-nitrofurans and related compounds with amino-heterocyclic substituents. J. Natl. Cancer Inst. 54: 841-850.[Web of Science][Medline]
[Order article via Infotrieve]
- Goodman DG, Ward JM, Squire RA, Chu KC, and Linhart MS (1979). Neoplastic and nonneoplastic lesions in aging F344 rats. Toxicol. Appl. Pharmacol. 48: 237-248.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Haseman JK, Arnold J., and Eustis SL (1990). Tumor incidences in Fischer 344 rats: NTP historical data. In: Pathology of the Fischer Rat. Reference and Atlas, GA Boorman, SL Eustis, MR Elwell, CA Montgomery Jr, and WF MacKenzie (eds). Academic Press, San Diego, California, pp. 555-564.
- Haseman JK, Hailey JR, and Morris RW (1998). Spontaneous neoplasm incidences in Fischer 344 rats and B6C3F, mice in two-year carcinogenicity studies: A National Toxicology Program update. Toxicol. Pathol. 26: 428-441.[Abstract/Free Full Text]
- Ho K-L. (1984). Ultrastructure of cerebellar capillary hemangioblastoma. 1. Weibel-Palade bodies and stromal cell histogenesis. J. Neuropathol. Exp. Neurol. 43: 592-608.[Web of Science][Medline]
[Order article via Infotrieve]
- Maekawa A., Kurokawa Y., Takahashi M., Kokubo T., Ogiu T., Onodera H., Tanigawa H., Ohno Y., Furukawa F., and Hayashi Y. (1983). Spontaneous tumors in F-344/DuCrj rats. Gann 74: 365-372.[Web of Science][Medline]
[Order article via Infotrieve]
- Maita K., Hirano M., Harada T., Mitsumori K., Yoshida A., Takahashi K., Nakashima N., Kitazawa T., Enomoto A., Inui K., and Shirasu Y. (1987). Spontaneous tumors in F344/DuCrj rats from 12 control groups of chronic and oncogenicity studies. J. Toxicol. Sci. 12: 111-126.[Medline]
[Order article via Infotrieve]
Toxicologic Pathology, Vol. 27, No. 4,
463-467 (1999)
DOI: 10.1177/019262339902700411
 CiteULike  Complore  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter What's this?
|
|
