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Commentary: Role of the Pathologist in the Identification and Characterization of Therapeutic Molecules

Department of Pathology, Genentech, Inc., South San Francisco, California 94080

References

• Baron WF, Pan CQ, Spencer SA, Ryan AM, Lazarus RA, and Baker KP (1998). Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages. Gene 215: 291-301.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Cacalano G., Farinas I., Wang LC, Hagler K., Forgie A., Moore M., Armanini M., Phillips H., Ryan AM, Reichardt LF, Hynes M., Davies A., and Rosenthal A. (1998). GFR1 is an essential receptor component for GDNF in the developing nervous system and kidney. Neuron 21: 53-62.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Cacalano G., Lee J., Kikly K., Ryan AM, Pitts-Meek S., Hultgren B., Wood WI, and Moore MW (1994). Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog. Science 265: 682-684.[Abstract/Free Full Text]
• Carpenter D., Stone DM, Brush J., Ryan AM, Armanini M., Frantz G., Rosenthal A., and de Sauvage FJ (1998). Characterization of two patched receptors for the vertebrate hedgehog protein family. Proc. Natl. Acad. Sci. USA 95: 13630-13634.[Abstract/Free Full Text]
• deSauvage FJ, Carver-Moore K., Luoh S-M., Ryan AM, Dowd M., Eaton D., and Moore MW (1996). Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin. J. Exp. Med. 183: 651-656.[Abstract/Free Full Text]
• Fong S., Jones S., Renz ME, Chiu HH, Ryan AM, Presta LD, and Jackson D. (1997). Mucosal addressin cell adhesion molecule-1 (MadCAM-1)—Its binding motif for 4β7 and role in experimental colitis. Immunol. Res. 16: 299-311.[Web of Science][Medline] [Order article via Infotrieve]
• Fox JA, Reitz B., Hagler K., Hsei V., Keller G., Ryan AM, Schoenhoff MB, and Widmer R. (1997). Pharmacokinetics and clearance mechanisms of anti-IgE:IgE monoclonal and polyclonal complexes. Pharm. Res. 14: S217 (abstract).
• Gerber HP, Hillan KJ, Ryan AM, Kowalski J., Keller G-A., Rangell L., Wright BD, Radtke F., Aguet M., and Ferrara N. (1999). VEGF is required for growth and survival in neonatal mice. Development 126: 1149-1159.[Abstract]
• Grupe A., Hultgren B., Ryan AM, Ma YH, and Stewart TA (1995). Transgenic knockouts reveal a critical requirement for beta cell glucokinase in maintaining glucose homeostasis. Cell 83: 69-78.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Hillan KJ, Hagler KE, MacSween Rnm, Ryan AM, Renz ME, Chiu HH, Ferrier RK, Bird GL, Dhillon AP, Ferrel LD, and Fong S. (1999). Expression of the mucosal vascular addressin MAdCAM-1 in inflammatory liver disease. Liver (in press).
• Jin H., Yang R., Keller G., Ryan AM, Ko A., Pennica D., Wood WI, and Paoni NF (1996). In vivo effects of cardiotrophin-1. Cytokine 8: 920-926.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Kimson PR, De Guzman GG, Keyt BA, Ryan AM, Keyt LK, Shen BQ, and Zioncheck TF (1998). Role of the heparin binding domain in the clearance and localization of vascular endothelial growth factor. J. Am. Coll. Cardiol. 31: 461A (abstract).
• Kimson PR, De Guzman GG, Keyt BA, Ryan AM, Keyt LK, and Zioncheck TF (1997). The heparin binding domain of vascular endothelial growth factor governs plasma clearance and tissue localization. Pharm. Res. 14: S366 (abstract).[CrossRef]
• Lew MA, Brown LA, Sehl PD, Ryan AM, Hillan KJ, and Lowe DG (1998). CARP expression in cardiac injury in the rat. FASEB J. 12: A709 (abstract).
• Lu H., Jin H., Yang R., Ogasawara A., Ryan AM, and Paoni NF (1999). Effects of growth hormone on gene expression in the normal and post-infarct rat heart. Circulation (in press).
• Moore MW, Klein RD, Farinas I., Sauer H., Armanini M., Phillips H., Reichardt LF, Ryan AM, Carver-Moore K., and Rosenthal A. (1996). Renal and neuronal abnormalities in mice lacking GDNF. Nature 382: 76-79.[CrossRef][Medline] [Order article via Infotrieve]
• Mordenti J., Cuthbertson RA, Ferrara N., Thomsen K., Berleau L., Licko V., Allen PC, Valverde CR, Meng YG, Fei Dtw, Fourre KM, and Ryan AM (1999). Comparison of the intraocular tissue distribution, pharmacokinetics and safety of 125I-labeled full length and Fab antibodies in Rhesus monkeys following intravitreal administration. Toxicol. Pathol. (in press).
• Mordenti J., Licko V., Thomsen K., Kahn J., Cuthbertson RA, Duenas E., Ryan AM, Schofield C., Berger T., Meng G., and Cleland J. (1999). Intraocular pharmacokinetics and safety of a humanized monoclonal antibody in rabbits after intravitreal administration of a solution or PLGA microsphere formulation. Toxicol. Sci. (in press).
• Osaka G., Carey K., Cuthbertson A., Godowski P., Patapoff T., Ryan A., Gadek T., and Mordenti J. (1996). Pharmacokinetics, tissue distribution and expression efficiency of plasmid [33P] DNA following intravenous administration of DNA/cationic lipid complexes in mice: Use of a novel radionucleotide approach. J. Pharm. Sci. 85: 612-618.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Roos F., Ryan AM, Chamow SM, Bennett GL, and Schwall RH (1995). Induction of liver growth in normal mice by infusion of hepatocyte growth factor/scatter factor. Am. J. Physiol. 268 (2 Pt 1): G380-G386.[Web of Science][Medline] [Order article via Infotrieve]
• Ryan AM, Bates Eppler D, Hagler KE, Bruner RH, Thomford PJ, Hall RL, Shopp GM, and O'Neill CA (1999). Preclinical safety evaluation of rhuMAbVEGF, an anti-angiogenic humanized monoclonal antibody. Toxicol. Pathol. 27: 78-86.[Abstract/Free Full Text]
• Ryan AM, Hagler K., Bodary S., Gadek T., Lopez P., Kowalski J., and Cuthbertson RA (1997). vβ3 and vβ5 protein localization in a rat corneal angiogenesis model and in age related macular degeneration specimens. Vet. Pathol. 34: 476 (abstract).
• Ryan AM, Hagler K., Cuthbertson RA, and Miller J. (1997). The role of VEGF and VEGFR expression in experimental choroidal neovascularization. Vet. Pathol. 34: 475 (abstract).
• Ryan AM, Hagler K., Moore M., and Carver-Moore K. (1997). Spontaneous renal disease in CD-1 GDNF heterozygous mice. Vet. Pathol. 34: 482 (abstract).
• Ryan AM, Kim I., Rohan R., Amano S., Agular S., Miller JW, and Adamis AP (1999). Constitutive expression of VEGF, VEGFR-1 and VEGFR-2 in normal eyes. Invest. Ophthalmol. Vis. Sci. (in press).
• Spencer SD, Di Marco F, Hooley J., Pitts-Meek S., Bauer M., Ryan AM, Sordat B., Gibbs VC, and Aguet M. (1998). The orphan receptor CRF 2-4 is an essential subunit of the interleukin-10 receptor. J. Exp. Med. 187: 571-578.[Abstract/Free Full Text]
• Wright BD, Klassen T., Keyt B., Hillan KJ, Ryan AM, and Cairns B. (1998). Immunolocalization of vascular endothelial growth factor (VEGF) and its receptors (Flt-1 and KDR/Flk-1) show distinct patterns in normal kidney. FASEB J. 12: A103 (abstract).
• Xie J., Murone M., Luoh S-M., Ryan A., Gu Q., Zhang C., Bonifas JM, Lam C-W., Hynes M., Goddard A., Rosenthal A., Epstein EH, and deSauvage FJ (1998). Activating smoothened mutations in sporadic basal cell carcinoma. Nature 391: 90-93.[CrossRef][Medline] [Order article via Infotrieve]

Toxicologic Pathology, Vol. 27, No. 4, 474-476 (1999)
DOI: 10.1177/019262339902700415


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This Article Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Ryan, A. M. Search for Related Content PubMed PubMed Citation Articles by Ryan, A. M. Social Bookmarking                         What's this?