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Dorsal Skin Reactions of Hairless Dogs to Topical Treatment with Corticosteroids

Research Center, Nihon Nosan Kogyo Co., Takura, Tsukuba, Ibaraki 300-2615, Japan

Kunio Doi

Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo, Yayoi, Bunkyo, Tokyo 113-8657, Japan

Dorsal skin reactions to continuous topical treatment with different types of corticosteroids were histologically investigated in hairless descendants of Mexican hairless dogs. The preparations tested were prednisolone (ST-1; weak), fluocinolone acetonide (ST-2; moderate), diflucortolone valrerate (ST-3; strong), and mometasone furoate (ST-4; very strong). Grossly, the sites treated with ST-3 and ST-4 showed moderate inflammatory reactions. After completion of the corticosteroid treatment, both sites were less pigmented and had a thin texture. The severity of histologic changes in the skin was dependent on the efficacy of the corticosteroids. The epidermis was prominently thinned from 1 wk after treatment with the corticosteroids, resulting in a flat dermis-epidermis junction. By the end of the corticosteroid treatment, these lesions became progressively more severe. At 2 wk after completion of topical treatment, the epidermal thickness in the sites treated with ST-1 and ST-2 began to return to normal values, whereas the epidermis of the skin treated with ST-3 and ST-4 became thinner. At 3-4 wk after topical treatment with ST-3 and ST-4, the dermis showed hyalinization of collagen bundles. These dermatologic findings in hairless dogs are in accordance with steroid-induced skin atrophy of human beings. These results suggest that the skin of hairless dogs responds sensitively to topical corticosteroids and that these animals are a useful model for investigating the efficacy and adverse effects of cutaneous topical corticosteroids.

Key Words: Adverse effects • animal models • dermal hyalinization • epidermal thinning • foamy cells • histology • inflammation • skin atrophy

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Toxicologic Pathology, Vol. 27, No. 5, 528-535 (1999)
DOI: 10.1177/019262339902700506


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Kimura, T. Articles by Doi, K. Search for Related Content PubMed PubMed Citation Articles by Kimura, T. Articles by Doi, K. Social Bookmarking                         What's this?