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The Use of Genetically Altered Animals in Toxicology
Joel F. Mahler
Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
Key Words: Genetically altered animals • animal modeling • altered genes • nontumor endpoints • carcinogenesis
References
- Ballatori N., Wang W., Lieberman MW (1998). Accelerated methylmercury elimination in y-glutamyl transpeptidase-deficient mice. Am J Pathol 152: 1049-1055.[Abstract]
- Battalora M., Tennant R. (1999). The use of transgenic mice in mutagenesis and carcinogenesis research and in chemical safety assessment. In: Molecular Biology of the Toxic Response, Puga A, Wallace K (eds). Taylor and Francis, Philadelphia, pp 111-126.
- Cadet JL, Sheng P., Ali S., Rothman R., Carlson E., Epstein C. (1994). Attenuation of methamphetamine-induced neurotoxicity in copper/ zinc superoxide dismutase transgenic mice. J Neurochem 62: 380-383.[Web of Science][Medline]
[Order article via Infotrieve]
- Campbell IL, Chiang CS (1995). Cytokine involvement in CNS disease: Implications from transgenic mice. Ann NY Acad Sci 771: 301-312.[Web of Science][Medline]
[Order article via Infotrieve]
- Cressman DE, Greenbaum LE, DeAngelis RA, Ciliberto G. Furth EE, Poli V., Taub R. ( 1996). Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science 274: 1379-1383.[Abstract/Free Full Text]
- Fernandez-Salguero PM, Hilbert DM, Rudikoff S., Ward JM, Gonzalez FJ (1996). Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity. Toxicol Appl Pharmacol 140: 173-179.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Friedberg EC, Meira LB, Cheo DL ( 1998). Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage. Mutat Res 407: 217-226.[Web of Science][Medline]
[Order article via Infotrieve]
- Gonzalez F., Fernandez-Salguero P., Lee S., Pineau T., Ward J. ( 1995). Xenobiotic receptor knockout mice. Toxicol Lett 82/83: 117-121.[CrossRef][Medline]
[Order article via Infotrieve]
- Lee S., Buters J., Pineau T., Fernandez-Salguero P., Gonzalez F. (1996). Role of CYP2E1 in the hepatotoxicity of acetaminophen. J Biol Chem 271: 12063-12067.[Abstract/Free Full Text]
- Liang Hcl, Li H., McKinnon RA, Duffy JJ, Potter SS, Puga A., Nebert DW (1996). Cypla2(—/—) null mutant mice develop normally but show deficient drug metabolism. Proc Natl Acad Sci USA 93: 1671-1676.[Abstract/Free Full Text]
- Lindzey J., Korach K. (1997). Developmental and physiological effects of estrogen receptor gene disruption in mice. TEM 8: 137-145.[Medline]
[Order article via Infotrieve]
- Lomnitski L., Kohen R., Chen Y., Shohami E., Trembovler V., Vogel T., Michaelson M. (1997). Reduced levels of antioxidants in brains of apolipoprotein E-deficient mice following closed head injury. Pharmacol Biochem Behav 56: 669-673.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Mahler JF, Davis BJ, Morham SG, Langenbach R. (1996). Disruption of cyclooxygenase genes in mice. Toxicol Pathol 24: 717-719.[Free Full Text]
- Maronpot RR (2000). The use of genetically modified animals in carcinogenicity bioassays. Toxicol Pathol 28:450-453 (this issue).[Free Full Text]
- Nebert D. Duffy J (1997). How knockout mouse lines will be used to study the role of drug-metabolizing enzymes and their receptors during reproduction and development, and in environmental toxicity, cancer, and oxidative stress. Biochem Pharmacol 53: 249-254.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Pinkert C. (1997). The history and theory of transgenic animals. Lab Anim 26: 29-34.[CrossRef]
- Przedborski S., Kostic V., Jackson-Lewis V., Naini AB, Simonetti S., Fahn S., Carlson E., Epstein CJ, Cadet JL (1992). Transgenic mice with increased copper/zinc superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. J Neurosci 12: 1658-1667.[Abstract]
- Ryffel B. (1995). Cytokine knockout mice: Possible application in toxicological research. Toxicology 105: 69-80.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Tu P., Gurney ME, Julien JP, Lee VM, Trojanowski JQ (1997). Oxidative stress, mutant SOD1, and neurofilament pathology in transgenic mouse models of human motor neuron disease. Lab Invest 76: 441-456.[Web of Science][Medline]
[Order article via Infotrieve]
- Valentine JL, Lee SS, Seaton MJ, Asgharian B., Farris G., Corton JC, Gonzalez FJ, Medinsky MA (1996). Reduction of benzene metabolism and toxicity in mice that lack cyp2e 1 expression. Toxicol Appl Pharmacol 141: 205-213.[Web of Science][Medline]
[Order article via Infotrieve]
- Ward JM, Peters JM, Perella CM, Gonzalez FJ (1998). Receptor and nonreceptor-mediated organ-specific toxicity of di(2ethylhexyl) phthalate (DEHP) in peroxisome-proliferator-activated receptor
 -null mice. Toxicol Pathol 26: 240-246.[Abstract/Free Full Text] - Yamada Y., Fausto N. (1998). Deficient liver regeneration after carbon tetrachloride injury in mice lacking type 1 but not type 2 tumor necrosis factor receptor. Am J Pathol 152: 1577-1589.[Abstract]
Toxicologic Pathology, Vol. 28, No. 3,
447-449 (2000)
DOI: 10.1177/019262330002800315
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