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The Use of Genetically Modified Animals in Carcinogenicity Bioassays
Robert R. Maronpot
Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, maronpot{at}niehs.nih.gov
Key Words: Carcinogenicity bioassays • harmonization of testing requirements • genetically modified mice • genetically altered models
References
- Ashby J. (1997). Identifying potential human carcinogens—The role of genetically altered rodents. Toxicol Pathol 25: 241-243.[Free Full Text]
- Interagency Coordinating Committee on the Validation of Alternative Methods (1997). Validation and Regulatory Acceptance of Toxicological Test Methods. A Report of the Ad Hoc Interagency Coordinating Committee on the Validation of Alternative Methods. Publication No 97-3981, Department of Health and Human Services, National Institutes of Health, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.
- Smith PF (1996). Third international conference on harmonization of technical requirements for registration of pharmaceuticals for human use—A toxicologist's perspective. Toxicol Pathol 24: 519-528.[Abstract/Free Full Text]
- Various authors (1998). Focus on: Genetically altered mouse cancer models. Toxicol Pathol 26: 461-584.[Abstract/Free Full Text]
Toxicologic Pathology, Vol. 28, No. 3,
450-453 (2000)
DOI: 10.1177/019262330002800316
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