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Cecal Torsion in Rodents Associated with Chronic Administration of Clinafloxacin

Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, Michigan 48105

The chronic toxicity of clinafloxacin, a fluoroquinolone antibacterial agent, was evaluated in multiple strains of mice and rats. In 5 separate studies, mice and rats that were orally administered up to 1,000 mg/kg of clinafloxacin from 9 to 104 weeks developed dose-related cecal dilatation and deaths that were attributable to cecal torsion. Cecal rupture was observed in association with torsion. Although cecal dilatation is commonly observed in rodents given antibacterials such as fluoroquinolones, cecal torsion has not been a reported sequelae to dilatation.

Key Words: Rodent • mice • rat • cecal torsion • cecal dilatation • fluoroquinolone • clinafloxacin

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Toxicologic Pathology, Vol. 28, No. 5, 643-648 (2000)
DOI: 10.1177/019262330002800502


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Courtney, C. L. Search for Related Content PubMed PubMed Citation Articles by Courtney, C. L. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Social Bookmarking                         What's this?