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Dandy-Walker Like Malformation in a Fischer-344 Rat

Department of Veterinary Pathology, College of Agriculture, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan

Takeshi Morikawa

Department of Veterinary Pathology, College of Agriculture, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan

Hisae Yasui

Department of Veterinary Pathology, College of Agriculture, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan

Jyoji Yamate

Department of Veterinary Pathology, College of Agriculture, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan

Takao Kotani

Department of Veterinary Pathology, College of Agriculture, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan

A spontaneous cerebellar malformation was found in a 32-day-old male Fischer 344 rat. The cerebellar malformation was composed of a vermis defect and markedly dilated fourth ventricle. The cerebellar hemispheres were separated, with the left hemisphere being smaller than the right one. Degenerative/inflammatory lesions consisting of macrophage/lymphocyte infiltration, spheroidal calcium depositions, and astrocytic gliosis were seen adjacent to the cerebral aqueduct. Abnormally arranged hyperplastic ependymal cells were observed beneath the fourth ventricle in the medulla oblongata. The gross findings of the present case resemble those of the human Dandy-Walker malformation. While a precise mechanism remains to be elucidated, degenerative/inflammatory lesions in the present rat may be involved in the pathogenesis of this malformation.

Key Words: Cerebellar malformation • vermis defect • fourth ventricle • histopathology • scar lesions • spontaneous

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Toxicologic Pathology, Vol. 28, No. 5, 694-696 (2000)
DOI: 10.1177/019262330002800509


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Kuwamura, M. Articles by Kotani, T. Search for Related Content PubMed PubMed Citation Articles by Kuwamura, M. Articles by Kotani, T. Social Bookmarking                         What's this?