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Toxicologic Pathology
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Reviews

Review Article: Inhalation Studies in Laboratory Animals—Current Concepts and Alternatives

Jurgen Pauluhn

Institute of Toxicology, Bayer AG, 42096 Wuppertal, Germany

Ulrich Mohr

Institute of Experimental Pathology, Hanover Medical School, 30625 Hanover, Germany

References

  • Abraham MH, Kumarsingh R., Cometto-Muniz JE, Cain WS ( 1998). An algorithm for nasal pungency thresholds in man. Arch Toxicol 72: 227-232.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Achmadi UF, Pauluhn J. (1998). Household insecticides: Evaluation and assessment of inhalation toxicity: A workshop summary. Exp Toxicol Pathol 50: 67-72.[Web of Science][Medline] [Order article via Infotrieve]
  • Aegl (1999). Draft—Standing Operating Procedures of the National Advisory Committee on Acute Exposure Guideline Levels for Hazardous Substances. April 30, 1999.
  • Alarie Y. (1966). Irritating properties of airborne materials to the upper respiratory tract. Arch Environ Health 13: 433-449.[Web of Science][Medline] [Order article via Infotrieve]
  • Alarie Y. (1973). Sensory irritation by airborne chemicals. Crit Rev Toxicol 2: 299[CrossRef]
  • Alarie Y. (1981). Dose-response analysis in animal studies: prediction of human responses. Environ Health Perspect 42: 9-13.[Web of Science][Medline] [Order article via Infotrieve]
  • Andersen ME (1995). What do we mean by... dose? Inhal Toxicol 7: 909-915.[CrossRef][Web of Science]
  • Astm (1984). Standard Test Method for Estimating Sensory Irritancy of Airborne Chemicals. ASTM Targetation: E 981-84. American Society for Testing and Materials, Philadelphia.
  • Aufderheide M., Mohr U. (1999). CULTEX—A new system and technique for the cultivation and exposure of cells at the air/liquid interface. Exp Toxicol Pathol 51:489-490.[Web of Science][Medline] [Order article via Infotrieve]
  • Bos Pmj, Zwart A., Reuzel Pgj, Bragt PC (1992). Evaluation of the sensory irritation test for the assessment of occupational health risk. Crit Rev Toxicol 21: 423-450.[CrossRef][Web of Science]
  • Brain JD, Mensah GA (1983). Comparative toxicology of the respiratory tract. Am Rev Respir Dis 128: S87-S90.[Web of Science][Medline] [Order article via Infotrieve]
  • Calabrese EJ (1983). Principles of Animal Extrapolation. Wiley Interscience Publications, New York.
  • Camus P., Nemery B. (1998). A novel cause for bronchiolitis obliterans organizing pneumonia: Exposure to paint aerosols in textile workshops. Eur Respir J 11: 259-262.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Chengelis CP (1990). Examples of alternative use in toxicology for common species. J Am Coll Toxicol 9: 319-342.[Web of Science]
  • Chien YW (1985). Transnasal Systemic Medication, Elsevier, New York.
  • Clottens FL, Verbeken EK, Demedts M., Nemery B. (1997). Pulmonary toxicity of components of textile paint linked to the Ardystil syndrome: Intratracheal administration in hamsters. Occup Environ Med 54: 376-387.[Abstract/Free Full Text]
  • Cometto-Muniz JE, Cain WS (1995). Relative sensitivity of the ocular trigeminal, nasal trigeminal and olfactory systems to airborne chemicals. Chem Senses 20: 191-198.[Abstract/Free Full Text]
  • Costa DL (1985). Interpretation of new techniques used in the determination of pulmonary function in rodents. Fundam Appl Toxicol 5: 423-434.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Costa DL, Lehmann JR, Slatkin DN, Popemoe EA, Drew RT ( 1983). Chronic airway obstruction and bronchiectasis in the rat after intratracheal bleomycin. Lung 161: 287-300.[Web of Science][Medline] [Order article via Infotrieve]
  • Costa DL, Tepper JS (1988). Approaches to lung function assessment in small mammals. In: Toxicology of the Lung, Gardner DE, Crapo JP (eds). Raven Press, New York, pp 147-174.
  • Costa DL, Tepper JS, Raub JA ( 1992). Interpretations and limitations of pulmonary function testing in small laboratory animals. In: Comparative Biology of the Normal Lung, Vol 1, Parent RA (ed). CRC Press, Boca Raton, Florida, pp 367-399.
  • DeGeorge JJ, Ahn CH, Andrews PA, Browner ME, Choi YS, Chun MY, Du T., Lee-Ham DY, McGuinn WD, Pei L., Sancillo LF, Schmidt W., Sheevers H., Sun CS, Tripathi S., Vogel WM, Whitehurst V., Williams S., Taylor AS (1997). Considerations for toxicology studies of respiratory drugs. Regul Toxicol Pharmacol 25: 189-193.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Diamond L., O'Donnell M. (1977). Pulmonary mechanics in normal rats. J Appl Physiol Respir Environ Exercise Physiol 43: 942-948.[Abstract/Free Full Text]
  • Directive 92/69/EEC. Journal of the European Community—Legal Specifications L 383 A, 35, December 29, 1992. B.2. Acute Toxicity—Inhalation, p 121.
  • Directive 94/79EEC. Journal of the European Community—Legal Specifications L 354, 16, December 21, 1994.
  • Dorato MA, Wolff RK (1991). Inhalation exposure technology, dosimetry, and regulatory issues. Toxicol Pathol 19: 373-383.[Web of Science][Medline] [Order article via Infotrieve]
  • Ecetoc ( 1995). European Centre for Ecotoxicology and Toxicology of Chemicals, Brussels. Assessment Factors in Human Health Risk Assessment. Technical Report no. 68.
  • Ecetoc ( 1997). European Centre for Ecotoxicology and Toxicology of Chemicals, Brussels, Pulmonary Toxicity of Polyalkylene Glycols. Technical Report 55.
  • European Standard (CEN) EN 481: 1993 D, July 1993. Workplace Atmospheres-Size Fraction Definitions for Measurement of Airborne Particles.
  • Folkesson HG, Matthay MA, Weström BR, Kim KJ, Karlsson BW, Hastings RH (1996). Alveolar epithelial clearance of protein. J Appl Physiol 80: 1431-1445.[Abstract/Free Full Text]
  • Gardner DE, Kennedy GL (1993). Methodologies and technology for animal inhalation toxicological studies. In: Toxicology of the Lung, 2nd ed, Gardner DE, Crapo JD, McClellan RO (eds). Raven Press, New York, pp 1-30.
  • Gordon CJ, Mohler FS, Watkinson WP, Rezvani AH (1988). Temperature regulation in laboratory mammals following acute toxic insult. Toxicology 53: 161-178.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Henderson RF (1989). Bronchoalveolar lavage: A tool for assessing the health status of the lung. In: Concepts in Inhalation Toxicology, McClellan RO, Henderson RF (eds). Hemisphere Publishing Corporation, New York, pp 415-444.
  • Henderson RF, Belinsky A. (1993). Biological markers of respiratory tract exposure. In: Toxicology of the Lung, Gardner DE, Crapo JD, McClellan RO (eds). Raven Press, New York, pp 253-282.
  • Hussain AA (1998). Intranasal drug delivery. Adv Drug Delivery Rev 26: 39-49.
  • Jaeger RJ, Gearhart JM (1982). Respiratory and metabolic response of rats and mice to formalin vapor. Toxicology 25: 299-309.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Jarabek AM (1995). Consideration of temporal toxicity challenges current default assumptions. Inhal Toxicol 7: 927-946.[CrossRef][Web of Science]
  • Kennedy GL (1989). Inhalation toxicology. In: Principles and Methods of Toxicology, 2nd ed, Wallace A (ed). Raven Press, New York, pp 361-382.
  • Kodavanti UP, Mehendale HM (1990). Cationic amphiphilic drugs and phospholipid storage disorder. Toxicol Rev 42: 327-354.
  • Lailey AF, Hill L., Lawston IW, Stantonn D., Upshall DG (1991). Protection by cysteine esters against chemically induced pulmonary edema. Biochem Pharmacol 42: S47-S54.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Likens SA, Mauderly JL (1982). Effect of elastase or histamine on single-breath N2 wash-out in the rat. J Appl Physiol Respir Environ Exercise Physiol 52: 141-146.[Abstract/Free Full Text]
  • Lippmann M., Schlesinger RB (1984). Interspecies comparison of particle deposition and mucociliary clearance in tracheobronchial airways. J Toxicol Environ Health 13: 441-449.[Web of Science][Medline] [Order article via Infotrieve]
  • Maff (1985). Agricultural Chemical Laws and Regulations, Japan (II). Society of Agricultural Chemical Industry. Acute Inhalation Toxicity Study, p 22.
  • Matthay MA, Folkesson HG, Campagna A., Kheradmand F. (1993). Alveolar epithelial barrier and acute lung injury. New Horizons 1: 613-622.[Medline] [Order article via Infotrieve]
  • Mauderly JL (1984). Respiratory function responses of animals and humans to oxidant gases and to pulmonary emphysema. J Toxicol Environ Health 13: 345-361.[Web of Science][Medline] [Order article via Infotrieve]
  • Mauderly JL (1986). Respiration of F344 rats in nose-only inhalation exposure tubes. J Appl Toxicol 6: 25-30.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Mauderly JL (1988). Comparisons of respiratory function responses of laboratory animals and humans. In: Inhalation Toxicology: The Design and Interpretation of Inhalation Studies and Their Use in Risk Assessment, Mohr U (ed). Springer-Verlag, Heidelberg, pp 245-261.
  • Mauderly JL (1989). Effect of inhaled toxicants on pulmonary function. In: Concepts in Inhalation Toxicology, McClellan RO, Henderson RF (eds). Hemisphere Publishing Corporation, New York, pp 347-401.
  • McClellan RO (1986). Health effects of diesel exhaust: A case study in risk assessment. Am Ind Hyg Assoc J 47: 1-13.[Web of Science][Medline] [Order article via Infotrieve]
  • Moss OR ( 1993). Inhalation toxicology: Sampling techniques related to control of exposure atmospheres. In: Aerosol Measurements—Principles, Techniques, and Applications, Willeke K, Baron PA (eds). Van Nostrand Reinhold, New York, pp 833-842.
  • Nerbrink O., Fagerström PO, Wendel T., Eirefelt S., Källén A., Marchner H., Dahlbäck M. (1997). A novel dry powder aerosol delivery system for real-time measurement of the inhaled dose to large animals (dogs). Aerosol Sci Tech 27: 147-161.[CrossRef][Web of Science]
  • Nielsen GD, Olsen J., Bakbo JC, Holst E. (1985). Propyl ether. I. Interaction with the sensory irritant receptor. Acta Pharmacol Toxicol 56: 158.[Medline] [Order article via Infotrieve]
  • Nieman GF (1985). Current concepts of lung-fluid balance. Respir Care 30: 1062-1076.
  • Nunn JF (1981). Applied Respiratory Physiology. Butterworth, London, pp 63-93.
  • O'Neil JJ, Raub JA ( 1984). Pulmonary function testing in small laboratory animals. Environ Health Perspect 56: 1-22.[Web of Science]
  • Oosting RS, van Iwaarden JF, van Bree L., Voerhof J., van Golde LM, Haagsman HP (1992). Exposure of surfactant protein A to ozone in vitro and in vivo impairs its interactions with alveolar cells. Am J Physiol 262: 63-68.
  • Oppts 870.1300 (1998). US-EPA Health Effects Test Guidelines 870.1300—Acute Inhalation Toxicity. United States Environmental Protection Agency, Office of Prevention, Pesticides and Toxic Substances, EPA 712C-98-193, August 1998.
  • Organization for Economic Cooperation and Development (OECD) (1981). Guideline for Testing of Chemicals No. 403. Acute Inhalation Toxicity, adopted May 12, 1981.
  • Paiva M., Yernault JC, van Eer de Weghe P., Englert M. (1975). A sigmoid model of the static volume-pressure curve of human lung. Respir Physiol 23: 317-323.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Pauluhn J. (1988). Different methods used in acute and subchronic inhalation studies of potential lung irritants, with particular attention to lung function measurements. In: Inhalation Toxicology— The Design and Interpretation of Inhalation Studies and Their Use in Risk Assessment, Mohr U (ed). Springer-Verlag, Heidelberg, pp 87-101.
  • Pauluhn J. (1989). A mechanistic approach to assess the inhalation toxicity and hazard of methylisocyanate and related aliphatic monoisocyanates. In: Assessment of Inhalation Hazards, Integration and Extrapolation Using Diverse Data, Mohr U (ed). Springer-Verlag, Heidelberg, pp 119-128.
  • Pauluhn J. (1994). Validation of an improved nose-only exposure system for rodents. J Appl Toxicol 14: 55-62.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Pauluhn J. (1998). Hazard identification and risk assessment of pyrethroids in the indoor environment. Appl Occup Environ Hyg 13(6): 469-478.
  • Pauluhn J., Bury D., Föst U., Gamer A., Hofmann T., Kunde M., Neustadt T., Schlede E., Wettig K., Westphal D. (1997). Acute inhalation testing: Considerations of technical and regulatory aspects. Arch Toxicol 71: 1-10.[Web of Science]
  • Pauluhn J., Emura M., Mohr U., Popp A., Rosenbruch M. (1999). Two week inhalation toxicity of polymeric diphenylmethane-4,4'-diisocyanate (PMDI) in rats: Analysis of biochemical and morphological markers of early pulmonary response. Inhal Toxicol 11: 1143-1163.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Pauluhn J., Kimmerle G. (1989). A new method for long-term inhalation toxicity studies for bronchospasmolytic aerosol formulations in dogs. J Appl Toxicol 9: 259-264.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Pauluhn J., Machemer LH (1998). Assessment of pyrethroid-induced paraesthesias: Comparison of animal model and human data. Toxicol Lett 96,97: 361-368.[CrossRef][Medline] [Order article via Infotrieve]
  • Pauluhn J., Machemer L., Kimmerle G., Eben A. ( 1988). Methodological aspects of the determination of the acute inhalation toxicity of spray-can ingredients. J Appl Toxicol 8: 431-437.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Pauluhn J., Rüngeler W., Mohr U. ( 1995). Phenyl isocyanate-induced asthma in rats following a 2-week exposure period. Fundam Appl Toxicol 24: 217-228.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Phalen RF (1984). Inhalation Studies: Foundations and Techniques, Animal Models. CRC Press, Boca Raton, Florida, pp 211-241.
  • Putman E., van Golde LMG, Haagsman HP (1997). Review: Toxic oxidant species and their impact on the pulmonary surfactant system. Lung 175: 75-103.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Reasor MJ (1981). Review paper on: Drug-induced lipidosis and the alveolar macrophage. Toxicology 20: 1-33.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Reasor MJ, Ogle C., Kacew S. (1989). Amiodarone-induced pulmonary toxicity in rats: Biochemical and toxicological characteristics. Toxicol Appl Toxicol 97: 122-131.
  • Reuzel Pgj, Arts Jhe, Lomax LG, Kuper CF, Gembardt C., Feron VJ, Löser E. (1994). Chronic inhalation toxicity and carcinogenicity study of respirable polymeric methylene diphenyl diisocyanate (polymeric MDI) aerosol in rats. Fundam Appl Toxicol 22: 195-210.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Robledo RF, Barber DS, Witten ML (1999). Modulation of bronchial cell barrier function by in vitro jet propulsion fuel 8 exposure. Toxicol Sci 51: 119-125.[Abstract/Free Full Text]
  • Schaper M. (1993). Development of a data base for sensory irritants and its use in establishing occupational exposure limits. Am Ind Hyg Assoc J 54: 488-544.[Web of Science][Medline] [Order article via Infotrieve]
  • Snipes MB (1989). Species comparison for pulmonary retention of inhaled particles. In: Concepts in Inhalation Toxicology, McClellan RO, Henderson RF (eds). Hemisphere Publishing Corporation, New York, pp 193-227.
  • Snipes MB (1989). Long-term retention and clearance of particles inhaled by mammalian species. Crit Rev Toxicol 20: 175-211.[Web of Science][Medline] [Order article via Infotrieve]
  • Snipes MB, Boecker BB, McClellan RO (1983). Retention of monodisperse aluminium silicate particles inhaled by dogs, rats and mice. Toxicol Appl Toxicol 69: 345-362.[CrossRef]
  • SOT (American Society of Toxicology) (1992). SOT commentary. Recommendations for the conduct of acute inhalation limit tests. Fundam Appl Toxicol 18: 321-327.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Su WY, Gordon T. (1996). Alterations in surfactant protein A after exposure to ozone. J Appl Pharmacol 80: 1560-1567.
  • Takahashi H., Yoshida M., Murao N., Maita K. (1994). Different lethality between micron-sized and submicron-sized aerosols of organophosphorus insecticide, chlorfenvinphos, in rats. Toxicol Lett 73: 103-111.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Takezawa J., Miller FJ, O'Neil JJ (1980). Single-breath diffusing capacity and lung volumes in small laboratory animals. J Appl Physiol Respir Environ Exercise Physiol 48: 1052-1059.[Abstract/Free Full Text]
  • Tepper JS, Costa DL, Lehmann JR (1993). Extrapolation of animal data to humans: Homology of pulmonary physiological responses with ozone exposure. In: Toxicology of the Lung, 2nd ed, Gardner DE, Crapo JD, McClellan RO (eds). Raven Press, New York, pp 217-251.
  • Tsuda S., Iwasaka M., Yoshida M., Ikeda T., Shirasu Y. (1986). Effect of particle size on inhalation toxicity of chlorfenvinphos. Jpn J Vet Sci 48: 729-737.[Web of Science]
  • Tyler WS, Coalson JJ, Stripp B. (1983). Comparative biology of the lung. Am Rev Respir Dis 128: 1-91.[Web of Science][Medline] [Order article via Infotrieve]
  • Van Golde LMG, Batenburg JJ, Robertson B. (1988). The pulmonary surfactant system: Biochemical aspects and functional significance. Physiol Rev 68: 374-455.[Free Full Text]
  • Vci (1999). Technical Guidance Document: Acute Inhalation Toxicity Testing. Verband der Chemischen Industrie (VCI), Germany, Draft of May 19, 1999.
  • Warheit DB (1989). Interspecies comparison of lung responses to inhaled particles and gases. Crit Rev Toxicol 20: 1-30.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Watkinson WP, Aileru AA, Dowd SM, Doerfler DL, Tepper JS, Costa DL (1993). Acute effects of ozone on heart rate and body temperature in the unanesthetized, unrestrained rat maintained at different ambient temperatures. Inhal Toxicol 5: 129-147.[CrossRef][Web of Science]
  • Watkinson WP, Gordon CJ (1993). Caveats regarding the use of the laboratory rat as a model for acute toxicological studies: Modulation of the toxic response via physiological and behavioral mechanisms. Toxicology 81: 15-31.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Wolff RK, Dorato MA (1993). Toxicologic testing of inhaled pharmaceutical aerosols. Crit Rev Toxicol 24: 343-369.

Toxicologic Pathology, Vol. 28, No. 5, 734-753 (2000)
DOI: 10.1177/019262330002800514


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