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Aromatase Inhibitors Prevent Spontaneous Granular Cell Tumors in the Distal Female Reproductive Tract of Sprague-Dawley Rats

Novartis Pharmaceuticals, East Hanover, New Jersey 07936, judit.markovits{at}pharma.novartis.com

Pritam S. Sahota

Novartis Pharmaceuticals, East Hanover, New Jersey 07936

We recently established diagnostic criteria for granular cell changes in the distal female reproductive tract of rats. In a review of control animals from 9 carcinogenicity studies, we found that approximately 23% of animals had granular cell alterations. Because estrogen may play a role in the pathogenesis of granular cell alterations, we reviewed tissue sections from carcinogenicity studies with 2 aromatase inhibitors and found compound-related decreases in the incidence of granular cell changes. Since these aromatase inhibitors selectively prevent the conversion of androgenic steroids to the corresponding estrogens, these data further suggest that estrogen may play a role in the pathogenesis of granular cell tumors of the reproductive tract of rats.

Key Words: Aromatase inhibitor • cervix • granular cell tumor • rat • vagina

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Toxicologic Pathology, Vol. 28, No. 6, 799-801 (2000)
DOI: 10.1177/019262330002800605


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Markovits, J. E. Articles by Sahota, P. S. Search for Related Content PubMed PubMed Citation Articles by Markovits, J. E. Articles by Sahota, P. S. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information Cervical Cancer Vaginal Cancer Social Bookmarking                         What's this?