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Toxicologic Pathology
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Malignant Theca Cell Tumor of Rat

Kiyokazu Ozaki

Research Institute of Drug Safety, Setsunan University, 45-1 Nagaotohge-cho, Hirakata, Osaka 573-0101, Japan, ozaki{at}pharm.setsunan.ac.jp

Isao Narama

Research Institute of Drug Safety, Setsunan University, 45-1 Nagaotohge-cho, Hirakata, Osaka 573-0101, Japan

A large-sized ovarian tumor of theca cell origin was found in a female rat. The mass was located in the right ovary position. Histologically, the tumor was covered by thin fibrous capsule and consisted of a solid area and an abundant necrotic area. Tumor cells were arranged in a storiform or whorled pattern. Connective tissue elements occasionally presented as bundles of dense collagen fibers. Fusiform to elongated cells had oval- to spindle-shaped nuclei with indistinct nucleoli. Large round nuclei and mitotic figures were scattered throughout the tumor cells. These cells were stained positively with S-100 but negatively with vimentin and {alpha}—smooth muscle actin. Tumor cells with abundant cytoplasm sometimes contained multiple small-sized lipid vacuoles.

Key Words: Theca cell tumor • rat • tumor • ovary

References

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Toxicologic Pathology, Vol. 28, No. 6, 829-831 (2000)
DOI: 10.1177/019262330002800610
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This Article
Right arrow Abstract Freely available
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Ozaki, K.
Right arrow Articles by Narama, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ozaki, K.
Right arrow Articles by Narama, I.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?