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Malignant Theca Cell Tumor of Rat

Research Institute of Drug Safety, Setsunan University, 45-1 Nagaotohge-cho, Hirakata, Osaka 573-0101, Japan, ozaki{at}pharm.setsunan.ac.jp

Isao Narama

Research Institute of Drug Safety, Setsunan University, 45-1 Nagaotohge-cho, Hirakata, Osaka 573-0101, Japan

A large-sized ovarian tumor of theca cell origin was found in a female rat. The mass was located in the right ovary position. Histologically, the tumor was covered by thin fibrous capsule and consisted of a solid area and an abundant necrotic area. Tumor cells were arranged in a storiform or whorled pattern. Connective tissue elements occasionally presented as bundles of dense collagen fibers. Fusiform to elongated cells had oval- to spindle-shaped nuclei with indistinct nucleoli. Large round nuclei and mitotic figures were scattered throughout the tumor cells. These cells were stained positively with S-100 but negatively with vimentin and —smooth muscle actin. Tumor cells with abundant cytoplasm sometimes contained multiple small-sized lipid vacuoles.

Key Words: Theca cell tumor • rat • tumor • ovary

References

• Alison RH, Morgan KT (1987). Ovarian neoplasms in F344 rats and B6C3F 1 mice. Environ Health Perspect 73: 91-106.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Alison RH, Morgan KT, Haseman KJ, Boorman GA (1987). Morphology and classification of ovarian neoplasms in F344 rats and (C57BL/6 X C3H)F1 mice. J Natl Cancer Inst 78: 1229-1243.[Web of Science][Medline] [Order article via Infotrieve]
• Alison RH, Morgan KT, Montgomery CA (1990). Ovary. In: Pathology of the Fischer Rat, Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF (eds). Academic Press, San Diego, California, pp 429-442.
• Frith CH, Zuna RE, Morgan K. (1981). A morphologic classification and incidence of spontaneous ovarian neoplasms in three strains of mice. J Natl Cancer Inst 67: 693-702.[Web of Science][Medline] [Order article via Infotrieve]
• Gregson RL, Lewis DJ, Abbott DP (1984). Spontaneous ovarian neoplasms of the laboratory rat. Vet Pathol 21: 292-299.[Abstract]
• Lewis DJ (1987). Ovarian neoplasia in the Sprague-Dawley rat. Environ Health Perspect 73: 77-90.[Web of Science][Medline] [Order article via Infotrieve]
• Maekawa A., Hayashi Y. (1987). Granulosa/theca cell tumor, ovary, rat. In: Genital System (Monograph on Pathology of Laboratory Animals), Jones TC, Mohr U, Hunt RD (eds). Springer-Verlag, Berlin, Germany, pp 15-21.
• Mohr U. (1997). 9. Female genital system. In: International Classification of Rodent Tumours: Part I-The Rat, Mohr U (ed). International Agency for Research on Cancer, Lyon, France, pp 20-21.
• Peluso JJ, Gordon LR (1992). Nonneoplastic and neoplastic changes in the ovary. In: Pathobiology of the Aging Rat, Mohr U, Dungworth DL, Capen CC (eds). ILSI Press, Washington, D.C., pp 351-364.

Toxicologic Pathology, Vol. 28, No. 6, 829-831 (2000)
DOI: 10.1177/019262330002800610


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Ozaki, K. Articles by Narama, I. Search for Related Content PubMed PubMed Citation Articles by Ozaki, K. Articles by Narama, I. Pubmed/NCBI databases Medline Plus Health Information Ovarian Cancer Social Bookmarking                         What's this?