|
Sign In to gain access to subscriptions and/or personal tools.
|
A Survey of Discriminant Methods Used in Toxicological Histopathology
Tom Holland
Covance, Otley Rd, Harrogate, N Yorks, HG3 1PY, United Kingdom, tom.holland{at}covance.com
A cluster survey of United Kingdom (UK)-based toxicological pathologists has been made of the methods used to discriminate treatment-related from spontaneous variation in histopathological material from toxicity studies. The response rate was 78% of 102 polled. Respondents overwhelmingly preferred methods based on grading or scoring lesions and comparatively avoided methods based on ranking, measuring, counting, pairwise comparisons, or overviewing. This preference was in spite of regarding parametric and ranking methods as both more powerful and specific than some commonly used scoring methods. Respondents were evenly divided on the use of blind examination and tended to avoid using historic material to form an opinion.
Key Words: Control-treated contrasts • examination strategies • treatment-related change.
References
- Haseman JK (1993). The value and limitation of a large source of control pathology data. In: Computerised Control Animal Pathology Databases, Ed. Maustlan JAN. Pub Centre for Medicines Research, Carshalton, London, pp 11—13.
- Arnold DL, Farber E., Krewski D. (1988). Carcinogenicity testing. Histopathology and the Blind Method. Comment Toxicology 2(2): 67— 80.
- Dodd DC (1988). Blind slide reading or the uninformed versus the informed pathologist. Comment on Toxicol 2(2): 81—92.
- Bucci TJ (1991). Evaluation of altered morphology. In: Handbook of Toxicological Pathology, Hascheck WM, Rousseaux CG (eds). Academic Press, New York, pp 23—35.
- Hascheck WM, Rousseaux CG (1998). Toxicological pathology: Morphological evaluation of toxicity. In: Fundamentals of Toxicological Pathology, —().Academic Press, New York, pp 12—13.
- Boorman GA, Eustic SL, Elwell MR, Montgomery CA, MacKenzie WF (1990). Pathology of the Fischer Rat. Academic Press, New York.
- Greaves P., Faccini JM (1984). RatHistopathology—Appendix. Academic Press, New York.
- Maronpot RR (1999). Pathology of the Mouse. Cache River Press Vienna, Illinois.
- Gopinath C., Prentice DE, Lewis DJ (1987). Atlas of Experimental Toxicological Pathology, MTP Press Ltd, Lancaster.
- Greaves P. (1990). Histopathology of Preclinical Toxicity Studies. Elselvier, Amsterdam.
- Glaister JR (1986). Principles of Toxicological Pathology. Taylor and Francis, London, pp 204—207.
Toxicologic Pathology, Vol. 29, No. 2,
269-273 (2001)
DOI: 10.1080/019262301317052567
 CiteULike  Complore  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter What's this?
This article has been cited by other articles:
|
|
|
|
 
T. Holland
The Comparative Power of the Discriminant Methods Used in Toxicological Pathology
Toxicol Pathol,
June 1, 2005;
33(4):
490 - 494.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
