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The Development and Regression of Deciduosarcomas and Other Lesions Caused by Estrogens and Progestins in Rabbits

Department of Pathology, The George Washington University Medical Center, Washington, DC 20037, resbcz{at}gwumc.edu

Olli A. Jänne

The Center for Biomedical Research, The Population Council, New York, New York 10021

Andrew A. Abraham

Department of Pathology, The George Washington University Medical Center, Washington, DC 20037

Harold A. Nash

The Center for Biomedical Research, The Population Council, New York, New York 10021

A series of experiments were conducted to study the histopathological effects of a combination of exogenous estrogens and progestins in mature rabbits. Estradiol (14—45 µ g/day) and levonorgestrel (30—233 µg/day) were administered by intravaginal or subdermal Silastic devices for various time intervals to study the development of lesions with time and to determine if lesions regressed following withdrawal of the steroids. The origin of splenic decidual tumors (primary or metastasis from the uterus) was determined by administering the same steroid combination to castrated male rabbits. It was determined that uterine decidualization is present after 7 days of steroid treatment and that neoplasms of decidual cells may appear in the uterus after only 30 days of steroid administration. Decidual changes were observed frequently in uterine arteries, often concurrent with infarct-like areas of necrosis of the uterine wall. Withdrawal of contraceptive steroids for 14—120 days after 60 days' administration resulted in atrophy and disappearance of decidual cells and decidual tumors. Decidual neoplasms developed in the spleen of all castrated male rabbits given subdermal steroids, demonstrating that these tumors can arise as primary neoplasms of the spleen. The foregoing lesions appear to be peculiar to the rabbit and, together with previous data, suggest the rabbit to be a poor model for evaluating the effects of contraceptive steroids in other species.

Key Words: Contraceptive steroids • decidual reaction • deciduosarcoma • estrogens • progestins • uterine cancer • vascular lesions.

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Toxicologic Pathology, Vol. 29, No. 4, 411-416 (2001)
DOI: 10.1080/01926230152499755


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Zook, B. C. Articles by Nash, H. A. Search for Related Content PubMed PubMed Citation Articles by Zook, B. C. Articles by Nash, H. A. Social Bookmarking                         What's this?