This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Coggins, C. R.E. Search for Related Content PubMed PubMed Citation Articles by Coggins, C. R.E. Social Bookmarking                         What's this?

Review Article: A Review of Chronic Inhalation Studies with Mainstream Cigarette Smoke, in Hamsters, Dogs, and Nonhuman Primates

Lorillard Tobacco Company, Greensboro, North Carolina 27420, USA, ccoggins{at}lortobco.com

This paper is the continuation of previously published work, a review limited to studies on rats and mice. This paper makes an identical evaluation as before, but, restricting the species being evaluated to representative studies of smoke-exposed hamsters, dogs (both by tracheostomy and by direct inhalation), and nonhuma n primates. As was seen previously, no statistically significant increase in the incidence of malignant tumors of the respiratory tract was found in any of the 3 species, even though very long exposures and high doses of smoke were used. All 5 of the species of laboratory animals commonly used to evaluate carcinogenic potential produce results with mainstream cigarette smoke that are at variance with the epidemiological evidence in smokers.

Key Words: Cigarette smoke • dog • hamster • inhalation toxicology • nonhuman primate • respiratory tract.

References

• Alden CL (1998). Lifetime mouse cancer tests—The end of an era? Toxicol Pathol 26: 584.[Free Full Text]
• Ando K., Yanagita T. (1981). Cigarette smoking in Rhesus monkeys. Psychopharmacology (Berl) 72: 117—127.[CrossRef][Medline] [Order article via Infotrieve]
• Auerbach O., Garfi nkel L. (1991). The changing pattern of lung carcinoma. Cancer 68: 1973—1977.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Auerbach O., Hammond EC, Kirman D., Garfi nkel L. (1970). Effects of cigarette smoking on dogs. II Pulmonary neoplasms. Arch Environ Health 21: 754—768.[Web of Science][Medline] [Order article via Infotrieve]
• Baumgartner H., Coggins CRE (1980). Description of a continuous-smoking inhalation machine for exposing small animals to tobacco smoke. Beitr Tabakforsch Intl 10: 169—174.
• Bernfeld P., Homburger F., Russfi eld AB (1974). Strain differences in the response of inbred Syrian hamsters to cigarette smoke inhalation. J Natl Cancer Inst 53: 1141—1157.[Web of Science][Medline] [Order article via Infotrieve]
• Bernfeld P., Homburger F., Soto E. ( 1983). Subchronic cigarette smoke inhalation studies in inbred Syrian golden hamsters that develop laryngeal carcinoma upon chronic exposure. J Natl Cancer Inst 71: 619—623.[Web of Science][Medline] [Order article via Infotrieve]
• Bernfeld P., Homburger F., SotoE., Pai KJ (1979). Cigarette smoke inhalation studies in inbred Syrian golden hamsters. J Natl Cancer Inst 63: 675—689.[Web of Science][Medline] [Order article via Infotrieve]
• Brazell RS, Stiff AC, Henderson GM, Jenkins RA, Romig PL, Auerbach O. (1984). Plasma nicotine and cotinine in tobacco smoke exposed beagle dogs. Toxicol Appl Pharmacol 73: 152—158.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Coggins CRE (2000). Letter to the editor. Toxicol Pathol 28: 754.[Free Full Text]
• Coggins CRE (1998). A review of chronic inhalation studies with mainstream cigarette smoke in rats and mice. Toxicol Pathol 26: 307—314.[Abstract/Free Full Text]
• Coggins CRE, Musy C., Ventrone R. (1982). Changes in the minute ventilation of rats exposed to different concentrations of tobacco smoke. Toxicol Lett 11: 181—185.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Cross FT, Palmer RF, Filipy RE, Dagle GE, Stuart BO (1982). Carcinogenic effects of radon daughters, uranium ore dust and cigarette smoke in beagle dogs. Health Phys 42: 33—52.[Web of Science][Medline] [Order article via Infotrieve]
• Davies TS, Lynch BS, Monro AM, Munro IC, Nestmann ER (2000). Rodent carcinogenicity tests need be no longer than 18 months: an analysis based on 210 chemicals in the IARC monographs. Food Chem Toxicol 38: 219—235.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Dontenwill WP, Chevalier HJ, Harke HP, Lafrenz U., Reckzeh G., Schneider B. (1974). Investigations on the effects of chronic cigarette-smoke inhalation in Syrian golden hamsters. J Natl Cancer Inst 51: 1781—1832.[Web of Science]
• Dontenwill WP, Reckzeh G., Stadler L. (1967). Berauchungsapparatu r fur laboratoriumstiere. Beitr Tabakforsch 4: 45—49.
• Hammond EC, Auerbach O., Kirman D., Garfi nkel L. (1970). Effects of cigarette smoking on dogs. I. Design of experiment, mortality, and fi ndings in lung parenchyma. Arch Environ Health 21: 740—753.[Web of Science][Medline] [Order article via Infotrieve]
• Hazleton Laboratories American, Inc. (1981). Inhalation Bioassay of Cigarette Smoke in Dogs. Effects of Nicotine and Carbon Monoxide on Atherogenesis. National Cancer Institute. Division of cancer cause and prevention. Smoking and health program, Vienna, Virginia, pp 1—291.
• Hoffmann D., Rivenson A., Hecht SS, Hilfrich J., Kobayashi N., Wynder EL (1979). Model studies in tobacco carcinogenesi s with the syrian golden hamster. Prog Exp Tumor Res 24: 370—390.[Medline] [Order article via Infotrieve]
• Homburger F., Bernfeld P., Russfi eld AB (1974). Cigarette smoke inhalation studies in inbred Syrian hamsters. In: Experimental Lung Cancer. Carcinogenesis and Bioassays' Karbe E, Park JF (eds). Springer-Verlag, New York, pp 320—330.
• Kobayashi N., Hoffmann D., Wynder EL (1974). A study of tobacco carcinogenesis. XII. Epithelial changes induced in the upper respiratory tracts of syrian golden hamsters by cigarette smoke. J Natl Cancer Inst 53: 1085— 1089.[Web of Science][Medline] [Order article via Infotrieve]
• Maddox WL, Dalbey WE, Guerin MR, Stokely JR, Creasia DA, Kendrick J. (1978). A tobacco smoke inhalation exposure device for rodents. Arch Environ Health 33: 64—71.[Web of Science][Medline] [Order article via Infotrieve]
• Park SS, Kikkawa Y., Goldring IP, Daly MM, Zelefsky M., Shim C., Spierer M., Morita T. (1977). An animal model of cigarette smoking in beagle dogs. Correlative evaluation of effects on pulmonary function, defense, and morphology. Am Rev Respir Dis 115: 971—979.[Web of Science][Medline] [Order article via Infotrieve]
• Piccirillo VJ (1981). Inhalation bioassay of cigarette smoke in dogs: Nicotine and PMO effects. Borriston Laboratories, Temple Hills, Maryland.
• Raymond TL, Delucia AJ, Bryant LR (1982). Failure of chronic cigarette smoke exposure to alter plasma lipoproteins of stumptailed macaques (Macaca arctoides). Atherosclerosis 41: 27—33.[Medline] [Order article via Infotrieve]
• Renne RA, Miller RA (1996). Microscopic anatomy of toxicologically important regions of the larynx of the rat, mouse and hamster. In: Monographs on Pathology of Laboratory Animals. Respiratory System, 2nd ed, Jones TC, Dungworth DL, Mohr U (eds). Springer-Verlag, New York, pp 43— 51.
• Rogers WR, Carey KD, McMahan CA, Montiel MM, Mott GE, Wigodsky HS, McGill HC (1988). Cigarette smoking, dietary hyperlipidemia, and experimental atherosclerosis in the baboon. Exp Mol Pathol 48: 135— 151.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Rogers WR, McCullough B., Caton JE (1981). Cigarette smoking by baboons: in vivo assessment of particulate inhalation using bronchoalveolar lavage to recover 14-C dotriacontane. Toxicology 20: 309—999.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Samet JM (1993). The epidemiology of lung cancer. Chest, 103: 20S—29S.[CrossRef][Medline] [Order article via Infotrieve]
• Sopori ML, Gairola CC, DeLucia AJ, Bryant LR, Cherian S. (1985). Immuneresponsivenes s of monkeys exposed chronically to cigarette smoke. Clin Immunol Immunopathol 36: 338—344.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Wanner A., Hirsch JA, Greeneltch DE, Swenson EW, Fore T. ( 1973). Tracheal mucus velocity in beagles after chronic exposure to cigarette smoke. Arch Environ Health 27: 370—371.[Web of Science][Medline] [Order article via Infotrieve]
• Wehner AP, Busch RH, Olson RJ (1974). Effect of chronic exposure to cigarette smoke on tumor incidence in the syrian golden hamster. In: Experimental Lung Cancer. Carcinogenesis and Bioassays, Karbe E, Park JF (eds). Springer-Verlag, New York, pp 360—368.
• Wehner AP, Busch RH, Olson RJ (1976). Effects of diethylnitrosamine and cigarette smoke on hamsters. J Natl Cancer Inst 56: 749—756.[Web of Science][Medline] [Order article via Infotrieve]
• Wehner AP, Busch RH, Olson RJ, Craig DK (1975). Chronic inhalation of asbestos and cigarette smoke by hamsters. Environ Res 10: 368— 383.[Medline] [Order article via Infotrieve]
• Wehner AP, Busch RH, Olson RJ, Craig DK (1975). Chronic inhalation of nickel oxide and cigarette smoke by hamsters. Am Ind Hyg Assoc J 36: 801—810.[Web of Science][Medline] [Order article via Infotrieve]
• Wehner AP, Olson RJ, Busch RH (1976). Increased life span and decreased weight in hamsters exposed to cigarette smoke. Arch Environ Health 31: 146—153.[Web of Science][Medline] [Order article via Infotrieve]
• Wynder EL (1998). The past, present, and future of the prevention of lung cancer. Cancer Epidemiol Biomarkers Prev 7: 735—748.[Abstract]
• Zwicker GM, Filipy RE, Park JF, Loscutoff SM, Ragan HA, Stevens DL (1978). Clinical and pathological effects of cigarette smoke exposure in beagle dogs. Arch Pathol Lab Med 102: 623—628.[Web of Science][Medline] [Order article via Infotrieve]

Toxicologic Pathology, Vol. 29, No. 5, 550-557 (2001)
DOI: 10.1080/019262301317226357


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				C. R. E. Coggins An Updated Review of Inhalation Studies with Cigarette Smoke in Laboratory Animals International Journal of Toxicology, July 1, 2007; 26(4): 331 - 338. [Abstract] [Full Text] [PDF]

This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Coggins, C. R.E. Search for Related Content PubMed PubMed Citation Articles by Coggins, C. R.E. Social Bookmarking                         What's this?