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Society of Toxicologic Pathology Position Paper: Diet as a Variable in Rodent Toxicology and Carcinogenicity Studies
James B. Nold
Pathology Associates-A Charles River Company, Durham, North Carolina 27713, jnold{at}criver.com
Kevin P. Keenan
Departments of Safety Assessment and Biometrics, Merck Research Laboratories, West Point, Pennsylvania 19486
Abraham Nyska
National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, North Carolina 27709
Mark E. Cartwright
Schering-Plough Research Institute, Lafayette, New Jersey 07848
References
- Abdo KM, Kari FW ( 1997). The sensitivity of the NTP bioassay for carcinogen hazard evaluation can be modulated by dietary restriction. Exp Toxic Pathol 48: 129—137.[Web of Science]
- Hart RW, Newmann DA, Robertson RT (eds.) (1995). Dietary Restriction: Implications for the Design and Interpretation of Toxicity and Carcinogenicity Studies. ILSI Press, Washington, DC.
- Keenan KP, Ballam GC, Soper KA, Laroque P., Coleman JB, Dixit R. (1999). Diet, caloric restriction, and the rodent bioassay. Toxicol Sci 52 (Suppl): 24—34.[Abstract]
- Keenan KP, Coleman JB, McCoy CL, Hoe C-M., Soper KA, LaroqueP. (2000). Chronic nephropathy in ad libitum overfed Sprague-Dawley rats and its early attenuation by increasing degrees of dietary (caloric) restriction to control growth. Toxicol Pathol 28: 788—798.[Abstract/Free Full Text]
- Keenan KP, Laroque P., Ballam GC, Soper KA, Dixit R., Mattson BA, Adams SP, Coleman JB (1996). The effects of diet, ad libitum overfeeding, and moderate dietary restriction on rodent bioassay: The uncontrolled variable in safety assessment. Toxicol Pathol 24: 757—768.[Abstract/Free Full Text]
- Kemi M., Keenan KP, McCoy C., Hoe C-M., Soper KA, Ballam GC, vanZwieten MJ (2000). The relative protective effects of moderate dietary restriction versus dietary modification on spontaneous cardiomyopathy in male Sprague-Dawley rats. Toxicol Pathol 28: 285—296.[Abstract/Free Full Text]
- Rao GN (1997). New nonpurified diet (NTP-2000) for rodents in the National Toxicology Program's toxicology and carcinogenesi s studies. JNutr 127:842S—846S.[Medline]
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- Rao GN, Morris RW, Seely JC (2001). Benefi cial effects at NTP-2000 diet on growth, survival and kidney and heart diseases of Fischer 344 rats in chronic studies. Toxicol sci (in press).
Toxicologic Pathology, Vol. 29, No. 5,
585-586 (2001)
DOI: 10.1080/019262301317226393
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