This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Moyer, C. F. Articles by Nyska, A. Search for Related Content PubMed PubMed Citation Articles by Moyer, C. F. Articles by Nyska, A. Social Bookmarking                         What's this?

Systemic Vascular Disease in Male B6C3F1 Mice Exposed to Particulate Matter by Inhalation: Studies Conducted by the National Toxicology Program

Pathology Associates, Raleigh, North Carolina 27606, USA

Urmila P. Kodavanti

Pulmonary Toxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA

Joseph K. Haseman

Biostatics Branch, National Institute of Environmental Health, Research Branch, Research Triangle Park, North Carolina 27709, USA

L. Costa

Pulmonary Toxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA

Abraham Nyska

Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA, nyska{at}niehs.nih.gov.

Epidemiological studies suggest an association between ambient particulate matter and cardiopulmonary diseases in humans. The mechanisms underlying these health effects are poorly understood. To better understand the potential relationship between particulate-matter-induced inflammation and vascular disease, a 2-phase retrospective study was conducted. Phase one included the review of heart, lung, and kidney tissues from high-dose and control male B6C3F1 mice exposed by inhalation to 9 particulate compounds for a 2-year period. The results showed that high-dose males developed significantly increased incidences of coronary and renal arteritis over controls in 2 of the 9 studies (indium phosphide and cobalt sulfate heptahydrate), while marginal increases in arteritis incidence was detected in 2 additional studies (vanadium pentoxide and gallium arsenide). In contrast, arteritis of the muscular arteries of the lung was not observed. Morphological features of arteritis in these studies included an influx of mixed inflammatory cells including neutrophils, lymphocytes, and macrophages. Partial and complete effacement of the normal vascular wall architecture, often with extension of the inflammatory process into the periarterial connective tissue, was observed. Phase 2 evaluated the heart, lung, kidney, and mesentery of male and female B6C3F1 mice from the 90-day studies of the 4 compounds demonstrating arteritis after a 2-year period. The results showed arteritis did not develop in the 90-day studies, suggesting that long-term chronic exposure to lower-dose metallic particulate matter may be necessary to induce or exacerbate arteritis.

Key Words: Air pollution • indium phosphide • cobalt sulfate heptahydrate • mouse • heart • arteritis.

References

• Bailer AJ, Portier CJ (1998). Effects of treatment-induced mortality and tumor-induced mortality on tests for carcinogenicity in small samples. Biometrics 44: 417—431.[CrossRef]
• Bolibar I., Kienast J., Thompson SG, Matthias R., Niessner H., Fechtrup C. (1993). Relation of fibrinogen to presence and severity of coronary artery disease is independent of other coexisting heart disease. Am Heart J 124: 1601—1605.
• Campen MJ, Nolan JP, Schladweiler MCJ, Kodavanti UP, Evansky PA, Costa DL, Watkinson WP (2001). Cardiovascular and thermoregulatory effects of inhaled PM-associated transition metals: A potential interaction between nickel and vanadium sulfate. Toxicol Sci 64: 243—252.[Abstract/Free Full Text]
• Dockery DW, Pope CA 3rd, Xu X., Spengler JD, Ware JH, Fay ME, Ferris BG (1993). An association between air pollution and mortality in six U.S. cities. N Engl J Med 329: 1753—1759.[Abstract/Free Full Text]
• Elwell MR, Mahler JF (1999). Heart, blood vessels and lymphatic vessels. In: Pathology of the Mouse. Reference and Atlas, Maronpot RR (ed). Cache River Press, Vienna, IL, pp 359—380.
• Speizer FE, Ernest E. (1993). The role of fibrinogen as a cardiovascular risk factor. Atherosclerosis 100: 1—12.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Gardner SY, Lehmann JR, Costa DL (2000). Oil fly ash-induced elevation of plasma fibrinogen levels in rats. Toxicol Sci 56: 175—180.[Abstract/Free Full Text]
• Harder SD, Soukup JM, Ghio AJ, Devlin RB, Becker S. (2001). Inhalation of PM2.5 does not modulate host defense or immune parameters in blood or lung of normal human subjects. Environ Health Perspect 1009(suppl 4): 599—604.
• Ikegami H., Shishido T., Ishida K., Hanada T., Nakayama H., Doi K. (2001). Histopathological and immunohistochemical studies on arteritis induced by fenoldopam, a vasodilator, in rats. Exp Toxic Pathol 53: 25—30.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Kadison P., Haynes BF (1988). Vasculitis, mechanisms of vessel damage. In: Inflammation, Basic Principles and Clinical Correlates, Gallin J, Goldstein IM, Snyderman RS (eds). Raven Press, New York, pp 703—717.
• Kodavanti UP, Costa DL, Bromberg PA (1998). Rodent models ofcardiopulmonary disease: Their potential applicability in studies of air pollutant susceptibility. Environ Health Perspect 106(suppl 1): 111—130.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Kodavanti UP, Schladweiler MC, Ledbetter AD, Watkinson WP, Campen MJ, Winsett DW, Richards JR, Crissman KM, Hatch GE, Costa DL (2000). The spontaneously hypertensive rat as a model of human cardiovascular disease: Evidence of exacerbated cardiopulmonary injury and oxidative stress from inhaled emission particulate matter. Toxicol Appl Pharmacol 164: 250—263.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• National Toxicology Program ( 1993). Toxicology and Carcinogenesis Studies of Talc (CAS NO. 14807-96-6) in F344/N Rats and B6C3F1 Mice (Inhalation Studies), Technical Report Series No. 421, Department of Health and Human Services, Public Health Service, Bethesda, Maryland.
• National Toxicology Program ( 1996A). Toxicology and Carcinogenesis Studies of Nickel Oxide (CAS NO. 1313-99-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies), Technical Report Series No. 451, Department of Health and Human Services, Public Health Service, Bethesda, Maryland.
• National Toxicology Program ( 1996B). Toxicology and Carcinogenesis Studies of Nickel Subsulfide (CAS NO. 12035-72-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies), Technical Report Series No. 453, Department of Health and Human Services, Public Health Service, Bethesda, Maryland.
• National Toxicology Program ( 1996C). Toxicology and Carcinogenesis Studies of Nickel Sulfate Hexahydrate (CAS NO. 10101-97-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies), Technical Report Series No. 454, Department of Health and Human Services, Public Health Service, Bethesda, Maryland.
• National Toxicology Program ( 1997). Toxicology and Carcinogenesis Studies of Molybdenum Trioxide (CAS NO. 1313-27-5) in F344/N Rats and B6C3F1 Mice (Inhalation Studies), Technical Report Series No. 462, Department of Health and Human Services, Public Health Service, Bethesda, Maryland.
• National Toxicology Program ( 1998). Toxicology and Carcinogenesis Studies of Cobalt Sulfate Heptahydrate (CAS NO. 10026-24-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies), Technical Report Series No. 471, Department of Health and Human Services, Public Health Service, Bethesda, Maryland.
• National Toxicology Program ( 2000A). Toxicology and Carcinogenesis Studies of Gallium Arsenide (CAS NO. 1303-00-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies), Technical Report Series No. 492, Department of Health and Human Services, Public Health Service, Bethesda, Maryland.
• National Toxicology Program ( 2000B). Toxicology and Carcinogenesis Studies of Indium Phosphide (CAS NO. 22398-80-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies), Board Draft, Technical Report Series No. 499, Department of Health and Human Services, Public Health Service, Bethesda, Maryland.
• National Toxicology Program (2001). Toxicology and Carcinogenesis Studies of Vanadium Pentoxide (CAS NO.1314-62-01) in F344/N Rats and B6C3F1 Mice (Inhalation Studies), Board Draft, Technical Report Series No. 507, Department of Health and Human Services, Public Health Service, Bethesda, Maryland.
• Nyska A., Herbert RA, Chan PC, Haseman JK, Hailey JR (1998). Theophylline-induced mesenteric periarteritis in F344/N rats. Arch Toxicol 72: 731—737.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Ogami A., Quinlan K., Chu F., Hards J., Vincent R., Van Eeden S., Hogg JC ( 2000). The effect of PM10 on atherosclerotic lesions in rabbits. Am J Respir Crit Care Med 161: A240.
• Pope AC, Verrier RL, Lovett EG, Larson AC, Raizenne ME, Kanner RE, Schwartz J., Villegas M., Gold DR, Dockery DW (1999). Heart rate variability associated with particulate air pollution. Am Heart J 138: 890—899.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Samet JM, Zeger SL, Dominici F., Curriero F., Coursac I., Dockery DW, Schwartz J., Zanobetti A. (2000). The National Morbidity, Mortality, and Air Pollution Study. Part II: Morbidity and mortality from air pollution in the United States. Res Rep Health Eff Inst 94: 5—70.[Medline] [Order article via Infotrieve]
• Schwartz J., Dockery DW (1992). Increased mortality in Philadelphia associated with daily air pollution concentrations. Am Rev Respir Dis 145: 600—604.[Web of Science][Medline] [Order article via Infotrieve]
• Takenaka S., Karg E., Roth C., Schulz H., Ziesenis A., Heinzmann U., Schramel P., Heyder J. (2001). Pulmonary and systemic distribution of inhaled ultrafine silver particles in rats. Environ Health Perpect 1009(suppl 4): 547—552.
• Watkinson WP, Campen MJ, Costa DL (1998). Arrhythmia induction after exposure to residual oil fly ash particles in a rodent model of pulmonary hypertension. Toxicol Sci 41: 209—216.[Abstract/Free Full Text]
• Watkinson WP, Campen MJ, Nolan JP, Costa DL (2001). Cardiovascular and systemic responses to inhaled pollutants in rodents: Effects of ozone and particulate matter. Environ Health Perspect 109(suppl 4): 539—546.[Web of Science][Medline] [Order article via Infotrieve]
• Yates DB, Maidenly JL (2001). Inhaled environmental/occupational irritants and allergens: Mechanisms of cardiovascular and systemic responses. Environ Health Perspect 1009(suppl 4): 479—482.

Toxicologic Pathology, Vol. 30, No. 4, 427-434 (2002)
DOI: 10.1080/01926230290105631


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				S. Rehm, R. A. Thomas, K. S. Smith, R. C. Mirabile, T. L. Gales, S. L. Eustis, and R. W. Boyce Novel Vascular Lesions in Mice Given a Non-Peptide Vitronectin Receptor Antagonist Toxicol Pathol, December 1, 2007; 35(7): 958 - 971. [Abstract] [Full Text] [PDF]

This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Moyer, C. F. Articles by Nyska, A. Search for Related Content PubMed PubMed Citation Articles by Moyer, C. F. Articles by Nyska, A. Social Bookmarking                         What's this?