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Toxicologic Pathology
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Recommended Approaches for the Evaluation of Testicular and Epididymal Toxicity

Lynda L. Lanning

BioReliance Corporation, Rockville, Maryland, 20850

Dianne M. Creasy

Huntingdon Life Sciences, East Millstone, New Jersey 08875

Robert E. Chapin

Pfizer Inc, Groton, Connecticut 06340

Peter C. Mann

Experimental Pathology Laboratory NorthEast, Galena, Maryland 21635

Norman J. Barlow

Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709

Karen S. Regan

Regan Path/Tox Services, Ashland, Ohio 44805

Dawn G. Goodman

Covance Laboratories Inc, Vienna, Virginia 22182

Key Words: Testis evaluation • fixation • histomorphology • methods • histopathology.

References

  • Bancroft JD, Stevens A., Turner DR (1990). Theory and Practice of Histological Techniques, 3rd ed. Churchill Livingstone, New York.
  • Berndtson WE, Neefus C., Foote RH, Amann RP (1989). Optimal replication for histometric analysis of testicular function in rats and rabbits. Fund Appl Toxicol 12: 291—302.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Blanchard KT, Lee J., Boekelheide K. (1998). Leuprolide, a gonadotropin-releasing hormone agonist reestablishes spermatogenesis after 2,5-hexanedione-induced irreversible testicular injury in the rat resulting in normalized stem cell factor expression. Endocrinol 139: 236—244.[Abstract/Free Full Text]
  • Boorman GA, Chapin RE, Mitsumori K. (1990). Testis and Epididymis. In: Pathology of the Fischer Rat: Reference and Atlas, Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF (eds). Academic Press, San Diego, pp 405—418.
  • Chapin RE, Conner MW (1999). Testicular histology and sperm parameters. In: An Evaluation and Interpretation of Reproductive Endpoints for Human Health Risk Assessment, Daston G, Kimmel C (eds). ILSI Press, Washington, DC, pp 28—41.
  • Chapin RE, Heindel JJ (1993). Methods in Toxicology. Volume 3. Part A: Male Reproductive Toxicology. Academic Press Inc, San Diego.
  • Chapin RE, Ku WW (1994). The reproductive toxicity of boric acid. Environ Health Persp 102, suppl 7: 87—91.
  • Chapin RE, Ross MD, Lamb JC ( 1984). Immersion fixation methods for glycol methacrylate embedded testes. Toxicol Pathol 12: 221— 227.
  • Chapin RE, Sloane RA, Haseman JK (1998). Reproductive endpoints in general toxicity studies: are they predictive. Reprod Toxicol 12: 489—494.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Chellman GJ, Bus JS, Working PK (1986). Role of epididymal inflammation in the induction of dominant lethal mutations in Fischer 344 rat sperm by methyl chloride. Proc Natl Acad Sci USA 83: 8087—8091.[Abstract/Free Full Text]
  • Clegg ED, CookJC, Chapin RE, Foster PMD, Daston GP (1997). Leydig cell hyperplasia and adenoma formation: Mechanisms and relevance to humans. Reprod Toxicol 11: 107—121.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Creasy DM (1997). Evaluation of testicular toxicity in safety evaluation studies: the appropriate use of spermatogenic staging. Toxicol Pathol 25: 119—131.[Abstract/Free Full Text]
  • Creasy DM (2001). Pathogenesis of male reproductive toxicity. Toxicol Pathol 29: 64—76.[Abstract/Free Full Text]
  • Creasy DM, Foster PMD (2001). Male reproductive system. Chapter 10. In: Handbook of Toxicologic Pathology, 2nd ed, Haschek W, Rousseaux C, Wallig M (eds). Academic Press Inc, San Diego, pp
  • Creasy DM, Jonassen H. (1999). Histological fixation of the testes: Use of Davidson's fluid as an alternative to Bouin's fluid. Vet Pathol 36: 518.
  • Foley GM (2001). Overview of male reproductive pathology. Toxicol Pathol 29: 49—63.[Abstract/Free Full Text]
  • Harleman JH (1997). Testicular toxicity: Regulatory guidelines—The end of formaldehyde fixation? Toxicol Pathol 25: 414—417.[Free Full Text]
  • Hess RA (1990). Quantitative and qualitative characteristics of the stages and transitions in the cycle of the rat seminiferous epithelium: Light microscopic observation of perfusion-fixed and plastic embedded testes. Biol Reprod 43: 525—542.[Abstract]
  • Hess RA (1998). Effects of environmental toxicants on the efferent ducts epididymis and fertility. J Reprod Fertil Suppl 53: 247—259.[Medline] [Order article via Infotrieve]
  • Hess RA, Chen P. ( 1992). Computer tracking of germ cells in the cycle of the seminiferous epithelium and prediction of changes in cycle duration in animals commonly used in reproductive biology and toxicology. J Androl 13: 185—190.[Abstract/Free Full Text]
  • Hess RA, Moore BJ (1993). Histological methods for evaluation of the testes. In: Methods in Toxicology, Volume 3, Part A. Male Reproductive Toxicology, Chapin RE, Heindel JJ (eds). Academic Press Inc, San Diego, CA, pp 86—94.
  • Hess RA, Schaeffer DJ, Eroschenko VP, Keen JE ( 1990). Frequency of the stages in the cycle of the seminiferous epithelium in the rat. Biol Reprod 43: 517—524.[Abstract]
  • James RW, Heywood R. (1979). Age-related variations in the testes and prostate of beagle dogs. Toxicology 12: 273—279.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Kawakami E., Tsutsui T., Ogasa A. (1991). Histological observations of the reproductive organs of the male dog from birth to sexual maturity. J Vet Med Sci 53: 241—248.[Web of Science][Medline] [Order article via Infotrieve]
  • Lantendresse JR, Warbrittion AR, Jonassen H., Creasy DM (2002). Fixation of testes and eyes using a modified Davidson's fluid: Comparison with Bouin's fluid and conventional Davidson's fluid. Toxicol Pathol, in press.
  • Leblond CP, ClermontY. (1952). Spermiogenesis ofrat, mouse, hamster, and guinea pig as revealed by the periodic acid-fuchsin sulfurous acid technique. Am J Anat 90: 167—215.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Knobil E., Neill J., Greenwald G., Markert C., Pfaff D. (1994). The Physiology of Reproduction, 2nd ed. Raven Press, New York.
  • Lee J., Richburg JH, Shipp E., Meistrich ML, Boekelheide K. (1999). The Fas system, a regulator of testicular germ cell apoptosis, is differentially up-regulated in Sertoli cell versus germ cell injury of the testis. Endocrinol 140: 852—858.[Abstract/Free Full Text]
  • Lee J., Richburg JH, Younkin SC, Boekelheide K. (1997). The Fas system is a key regulator of germ cell apoptosis in the testis. Endocrinol 138: 2081— 2088.
  • Linder RE, Strader LF, Slott VL, Suarez JD (1992). Endpoints of spermatotoxicity in the rat after short duration exposures to 14 reproductive toxicants. Reprod Toxicol 6: 491—505.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Meistrich ML (1986). Critical components of testicular function and sensitivity to disruption. Biol Reprod 34: 17—28.[Abstract]
  • Nolte T., Harleman JH, Jahn W. ( 1995). Histopathology of chemically induced testicular atrophy in rats. Exp Toxicol Pathol 47: 267—286.[Web of Science][Medline] [Order article via Infotrieve]
  • Rehm S. (2000). Spontaneous testicular lesions in purpose bred beagle dogs. Toxicol Pathol 28: 782—787.[Abstract/Free Full Text]
  • Russell LD, Ettlin RA, Sinha Hikim AP, Clegg ED (1990). Histological and histopathological evaluation of the testis. Cache River Press, Clearwater, FL, pp 62—193.
  • Russell LD, Griswold MD (ed). (1993). The Sertoli Cell. Cache River Press, Clearwater, Florida.
  • Sprando RL (1990). Perfusion of the rat testis through the heart using heparin. In: Histological and Histopathological Evaluation of the Testes, Russell LD, Ettlin R, Sinha Hikim AP, Clegg ED (eds). Cache River Press, Florida, pp 277—280.
  • Wolfe L. (1978). Age and sexual behavior of Japanese macaques (Macaca fuscata). Arch Sexual Behav 7(1): 55—68.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]

Toxicologic Pathology, Vol. 30, No. 4, 507-520 (2002)
DOI: 10.1080/01926230290105695


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