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Factors Affecting the Interpretation of Canine and Nonhuman Primate Clinical Pathology

Covance Laboratories Inc, Madison, Wisconsin, robert.hall{at}covance.com

Nancy E. Everds

DuPont Haskell Laboratory, Newark, Delaware

Interpreting canine and nonhuman primate clinical pathology data from preclinical studies can be challenging. Relatively few animals are tested (typically beagles and macaques), and they often undergo study-related procedures (eg, sample collection for pharmacokinetic analysis) that can affect clinical pathology test results. Data interpretation requires an understanding of the significance of each test, species differences for each test, normal interanimal and intraanimal variability, the effects of study design variables, and supporting data from other disciplines. Interpretation of hematology, coagulation, clinical chemistry, and urinalysis parameters are discussed, with emphasis on species peculiarities and study design variables that may affect clinical pathology test results.

Key Words: Clinical • pathology • canine • primate • macaque • hematology • chemistry • urinalysis.

References

• Butterfield L. (1997). Are there just "races" (subspecies) of cynomolgus monkeys or should the name of Macaca irus be revived? Lab Primate Newslett 36: 19.
• Dodds WJ (1997). Hemostasis. In: Clinical Biochemistry of Domestic Animals, Fifth Edition, Kaneko JJ, Harvey JW, Bruss ML (eds). Academic Press, San Diego, CA, pp 241—284.
• Donovan J., Stokes WS, Montrey RD, Rozmiarek H. (1983). Hematologic characterization of naturally occurring malaria (Plasmodium inui) in cynomolgus monkeys (Macaca fascicularis). Lab Anim Sci 33: 86—89.[Web of Science][Medline] [Order article via Infotrieve]
• Hall RL ( 2001). Principles of clinical pathology for toxicology studies. In: Principles and Methods of Toxicology, Hayes AW (ed). Taylor & Francis, Philadelphia, PA, pp 1001—1038.
• Harvey JW (1997). The erythrocyte: Physiology, metabolism, and biochemical disorders. In: Clinical Biochemistry of Domestic Animals, Fifth Edition, Kaneko JJ, Harvey JW, Bruss ML (eds). Academic Press, San Diego, CA, pp 157—204.
• Hoffman WE, Wilson BW, Solter PF (1999). Clinical enzymology. In: The Clinical Chemistry of Laboratory Animals, Second Edition, Loeb WF, Quimby FW (eds). Taylor & Francis, Philadelphia, PA, pp 399—454.
• Jain NC ( 1986). Normal values in blood of laboratory, fur-bearing, and miscellaneous zoo, domestic, and wild animals. In: Schalm's Veterinary Hematology, Fourth Edition, Lea & Febiger, Philadelphia, PA, pp 274—349.
• Lappin PB, Thomas CA (2001). Subsets of peripheral blood lymphocytes differ in cynomolgus monkeys obtained from distinct geographical regions. Toxicologist 60: 262.
• Loeb WF ( 1999). The nonhuman primate. In: The Clinical Chemistry of Laboratory Animals, Second Edition, Loeb WF, Quimby FW (eds). Taylor & Francis, Philadelphia, PA, pp 145—162.
• Mandell CP, George JW (1991). Effect of repeated phlebotomy on iron status in rhesus monkeys (Macaca mulatta). Am J Vet Res 52: 728— 733.[Web of Science][Medline] [Order article via Infotrieve]
• Nguyen HT (1999). Transport proteins. In: The Clinical Chemistry of Laboratory Animals, Second Edition, Loeb WF, Quimby FW (eds). Taylor & Francis, Philadelphia, PA, pp 309—335.
• Rosol TJ, Capen CC (1997). Calcium-regulating hormones and diseases of abnormal mineral (calcium, phosphorus, and magnesium) metabolism. In: Clinical Biochemistry of Domestic Animals, Fifth Edition, Kaneko JJ, Harvey JW, Bruss ML (eds). Academic Press, San Diego, CA, pp 619— 702.
• Schofield LD, Bennett BT, Collins WE, Beluhan FZ (1985). An outbreak of Plasmodium inui malaria in a colony of diabetic rhesus monkeys. Lab Anim Sci 35: 167—168.[Web of Science][Medline] [Order article via Infotrieve]
• Slighter RG, Kimball JP, Barbolt TA, Sherer AD, Drobeck HP (1988). Enzootic hepatitis A infection in cynomolgus monkeys (Macaca fascicularis). Am J Primatol 14: 73—81.[CrossRef][Web of Science]
• Vahle J., Boldt H., Arnold T. (1997). Tissue distribution of creatine kinase in cynomolgus monkeys. Vet Pathol 34: 472.[Web of Science]

Toxicologic Pathology, Vol. 31, No. 1 suppl, 6-10 (2003)
DOI: 10.1080/01926230390174878


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Hall, R. L. Articles by Everds, N. E. Search for Related Content PubMed PubMed Citation Articles by Hall, R. L. Articles by Everds, N. E. Social Bookmarking                         What's this?