This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Haseman, J.K. Search for Related Content PubMed PubMed Citation Articles by Haseman, J.K. Social Bookmarking                         What's this?

An Alternative Perspective: A Critical Evaluation of the Waddell Threshold Extrapolation Model in Chemical Carcinogenesis

Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709

In a recent Perspective article (Toxicologic Pathology 31: 260—262, 2003) Waddell asserts that he has developed a log linear extrapolation model that can demonstrate a threshold and resolve for once and for all the uncertainies associated with low dose cancer risk extrapolation. However, his method essentially forces, rather than demonstrates, a threshold, and has many serious flaws that result in significant under-estimation of low dose risk. It would be a serious mistake for the scientific community to adopt Waddell's log linear extrapolation model for chemical carcinogenesis risk assessment.

Key Words: Carcinogenesis • thresholds • extrapolation • risk assessment.

References

• Haseman JK (1983). A re-examination of false-positive rates for carcinogenesis studies. Fund Appl Toxicol 3: 334—339.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Haseman JK (1985). Isssues in carcinogenicity testing: Dose selection. Fund Appl Toxicol 5: 66—78.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Rozman KK, Kerecsen L., Viluksela MK, Osterle D., Deml E., Viluksela M., Stahl BU, Greim H., Doull J. (1996). A toxicologist's view of cancer risk assessment. Drug Metab Rev 28: 29—52.[Web of Science][Medline] [Order article via Infotrieve]
• Waddell WJ (2002). Thresholds of carcinogenicity of flavors. Toxicol Sci 68: 275—279.[Abstract/Free Full Text]
• Waddell WJ (2003). Thresholds of carcinogenesis in the ED01 study. Toxicol Sci 72: 158—163.[Abstract/Free Full Text]
• Waddell WJ (2003). Threshold of carcinogenicity of nitrosodiethylamine for esophageal tumors in rats. Food Chem Toxicol (in press).
• Waddell WJ (2003). Comparison of human exposures to selected chemicals with thresholds from NTP carcinogenicity studies in rodents. Hum Exp Toxicol (in press).
• Waddell WJ (2003). Thresholds in chemical carcinogenesis: What are animal experiments telling us? Toxicologic Pathology 31: 260—262.

Toxicologic Pathology, Vol. 31, No. 5, 468-470 (2003)
DOI: 10.1080/01926230390228940


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Haseman, J.K. Search for Related Content PubMed PubMed Citation Articles by Haseman, J.K. Social Bookmarking                         What's this?