|
Sign In to gain access to subscriptions and/or personal tools.
|
Malignant Myoepithelioma with a Squamous Epithelial Component in the Mammary Gland of a Cynomolgus Monkey
Xiuying Yang
Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd, 2438 Miyanoura, Yoshida, Kagoshima 891-1394, Japan, xyyang{at}snbl.co.jp
Takao Hori
Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd, 2438 Miyanoura, Yoshida, Kagoshima 891-1394, Japan
Ayako Fukuda
Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd, 2438 Miyanoura, Yoshida, Kagoshima 891-1394, Japan
Yasuhiro Kamimura
Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd, 2438 Miyanoura, Yoshida, Kagoshima 891-1394, Japan
Kimiaki Hirakawa
Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd, 2438 Miyanoura, Yoshida, Kagoshima 891-1394, Japan
Hiroshi Maeda
Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd, 2438 Miyanoura, Yoshida, Kagoshima 891-1394, Japan
Hiroaki Miyajima
Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd, 2438 Miyanoura, Yoshida, Kagoshima 891-1394, Japan
A solid mass arising from the mammary gland was found in a 7-year-old female cynomolgus monkey. Histologically, the mass consisted of 2 components: spindle-shaped or ovoid sarcomatous cells and squamous epithelial cells. Metastatic nodules noted in the lung, liver and the gallbladder had the same histological features as the mammary mass. Immunohistochemistry revealed that the sarcomatous cells were positive for alpha-smooth muscle actin ( -SMA), vimentin, calponin, S-100 protein, epithelial membranous antigen (EMA), cytokeratin (large spectrum) and cytokeratin 14 (CK 14) in the cytoplasm, and p53, erbB-2 and progesterone receptor in the nuclei, but negative for desmin and estrogen receptor. The squamous epithelial cells were positive for EMA, cytokeratin (large spectrum) and CK 14, but negative for the rest. Both sarcomatous and squamous epithelial components were negative for glial fibrillary acidic protein (GFAP). Based on histological and immunohistochemical features, the present case was diagnosed as a malignant myoepithelioma with a squamous epithelial component in the mammary gland with distant metastases.
Key Words: Malignant myoepithelioma • squamous metaplasia • mammary gland • cynomolgus monkey • immunohistochemical staining.
References
- Appleby E., Kegmer H., Hime G. ( 1974). Three cases of suspected mammary neoplasis in nonhuman primates. J Comp Pathol 84: 351—354.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Beniashvili DS (1989). An overview of the world literature on spontaneous tumors in nonhuman primates. J Med Primatol 18(6): 423—437.[Web of Science][Medline]
[Order article via Infotrieve]
- Bigotti G., Di Giorgio CG (1986). Myoepithelioma of the breast: Histologic, immunologic, and electromicroscopic appearance. J Surg Oncol 32(1): 58— 64.
- Bult P., Verwiel JM, Wobbes T., Kooy-Smits MM, Biert J., Holland R. (2000). Malignant adenomyoepithelioma of the breast with metastasis in the thyroid gland 12 years after excision of the primary tumor. Case report and review of the literature. Virchows Arch 436(2): 158—166.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Chen PC, Chen CK, Nicastri AD, Wait RB ( 1994). Myoepithelial carcinoma of the breast with distant metastasis and accompanied by adenomyoepitheliomas. Histopathology 24: 543—548.[Web of Science][Medline]
[Order article via Infotrieve]
- Choi JH, Yoon BI, Kim JH, Shin NS, Kwon SW, Lee KW, Kim DY (2001). Mammary gland adenocarcinoma in a mandrill (Mandrillus sphinix). J Vet Med Sci 63(11): 1233—1235.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Cohen M., Saidla JE, Schlafer DH (2001). A spontaneously occurring mammary gland ductal carcinoma in situ in a rhesus macaque (Macaca mulatta) and a review of spontaneous mammary gland tumors in rhesus monkeys. J Med Primatol 30(2): 121—126.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Erlandson RA, Rosen PP (1982). Infiltrating myoepithelioma of the breast. Am J Surg Pathol 6: 785—793.[Web of Science][Medline]
[Order article via Infotrieve]
- Eydelloth RS, Swindle MM (1983). Intraductal mammary carcinoma and benign ovarian teratoma in a rhesus monkey. J Med Primatol 12(2): 101— 105.[Web of Science][Medline]
[Order article via Infotrieve]
- Hubbard GB, Wood DH, Butcher WI (1984). Mammary carcinoma with metastasis in a rhesus monkey (Macaca mulatta). Vet Pathol 21(5): 531— 533.[Web of Science][Medline]
[Order article via Infotrieve]
- Jabi M., Dardick I., Cardigos N. (1988). Adenomyoepithelioma of the breast. Arch Pathol Lab Med 112: 73—76.[Web of Science][Medline]
[Order article via Infotrieve]
- Japanese Association for Laboratory Animal Science (1987). Guidelines for Laboratory Animal Science. Exp Anim 36: 285—288.
- Kihara M., YokomiseH., Irie A., Kobayashi S., Kushida Y., Yamauchi A. (2001). Malignant adenomyoepithelioma of the breast with lung metastases: Report of a case. Surg Today 31(10): 899—903.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Lapin BA (1982). Use of nonhuman primates in cancer research. J Med Primatol 11(6): 327—341.[Web of Science][Medline]
[Order article via Infotrieve]
- Loose JH, Patchefsky AS, Hollander IJ, Lavin LS, Cooper HS, Katz SM ( 1992). Adenomyoepithelioma of the breast. A spectrum of biologic behavior. Am J Surg Pathol 16(9): 868—876.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Saez A., Serrano T., Azpeitia D., Condom E., Moreno A. (1992). Adenomyoepithelioma of the breast, a report of two cases. Arch Pathol Lab Med 116: 36—38.[Web of Science][Medline]
[Order article via Infotrieve]
- Shirashi T., Nakayama T., Fukutome K., Watanabe M., Murata T. (1999). Malignant myoepithelioma of the breast metastasizing to the jaw. Virchows Arch 435(5): 520—523.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Tavassoli FA (1991). Myoepithelial lesions of the breast. Myoepitheliosis, adenomyoepithelioma, and myoepithelial carcinoma. Am J Surg Pathol 15(6): 554—568.[Web of Science][Medline]
[Order article via Infotrieve]
- Toth J. (1977). Benign human mammary myoepithelioma. Virchows Arch A Pathol Anat Histol 374(3): 263—269.[CrossRef][Medline]
[Order article via Infotrieve]
- Trojani M., Guiu M., Trouette H., De Mascarel I., Cocquet M. (1992). Malignant adenomyoepithelioma of the breast. An immunohistochemical, cytophotometric, and ultrastructural study of a case with lung metastases. Am J Clin Pathol 98(6): 598—602.[Web of Science][Medline]
[Order article via Infotrieve]
- Uno H. (1997). Age-related pathology and biosenescent markers in captive rhesus macaques. Age 20: 1—13.[CrossRef][Web of Science]
- Van Dorpe J., De Weer F., Bekaert J., Lauweryns J., Moerman P. (1996). Malignant myoepithelioma of the breast. Case report with immunohistochemical study. Arch Anat Cytol Pathol 44(4): 193—198.[Medline]
[Order article via Infotrieve]
- Waggie KS, Tolwani RJ, Lyons DM (2000). Mammary adenocarcinoma in a male squirrel monkey (Saimiri sciureus). Vet Pathol 37(5): 505— 507.
- Wang J., Dong F., Wang X. ( 1996). Expression of c-erbB-2 oncogene and mutation of p53 gene in myoepithelioma and myoepithelial carcinoma. Zhonghua Kou Qiang Yi Xue Za Zhi 31(2): 71—73.[Medline]
[Order article via Infotrieve]
- Weidner N., Levine JD (1988). Spindle-cell adenomyoepithelioma of the breast. A microscopic, ultrastructural, and immunocytochemical study. Cancer 62: 1561—1567.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Zarbo RJ, Oberman HA (1983). Cellular adenomyoepithelioma of the breast. Am J Surg Pathol 7: 863—870.[Web of Science][Medline]
[Order article via Infotrieve]
Toxicologic Pathology, Vol. 31, No. 5,
549-553 (2003)
DOI: 10.1080/01926230390226672
 CiteULike  Complore  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter What's this?
|
|
