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Reviews

Effects of Exogenous Melatonin—A Review

Vladimir N. Anisimov

Department of Carcinogenesis and Oncogerontology, N.N. Petrov Research Institute of Oncology, St. Petersburg 197758, Russia, aging{at}mail.ru; geros{at}land.ru

The results of studies on the effect of pineal indole hormone melatonin on the life span of mice, rats, fruit flies, and worms are critically reviewed. In mice, long-term administration of melatonin was followed by an increase in their life span in 12 experiments and had no effect in 8 of 20 different experiments. In D. melanogaster , the supplementation of melatonin to the nutrient medium during developmental stages gave contradictory results, but when melatonin was added to food throughout the life span, an increase in the longevity of fruit flies has been observed. Melatonin decreased the survival of C. elegans but increased the clonal life span of planaria Paramecium tertaurelia. Available data suggest antioxidant and atherogenic effects of melatonin. Melatonin alone turned out to be neither toxic nor mutagenic in the Ames test and revealed clastogenic activity in high concentration in the COMET assay. Melatonin inhibits mutagenesis induced by irradiation and by indirect chemical mutagens and inhibits the development of spontaneous and chemical-induced tumors in mice and rats. Further studies and clinical trials are needed to verify that melatonin is both safe and has geroprotector efficacy for humans.

Key Words: Melatonin • life span • longevity • tumorigenesis • mouse • rat • fruit fly • worm.

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Toxicologic Pathology, Vol. 31, No. 6, 589-603 (2003)
DOI: 10.1080/01926230390257885
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X. Ma, C. Chen, K. W. Krausz, J. R. Idle, and F. J. Gonzalez
A Metabolomic Perspective of Melatonin Metabolism in the Mouse
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