Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
Toxicologic Pathology
This Article
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Lehman-Mckeeman, L. D.
Right arrow Articles by Car, B. D.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Lehman-Mckeeman, L. D.
Right arrow Articles by Car, B. D.
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Metabonomics: Application in Predictive and Mechanistic Toxicology

Lois D. Lehman-Mckeeman

Discovery Toxicology, Bristol-Myers Squibb Company, Princeton, New Jersey 08543, USA, Lois.lehman-mckeeman{at}bms.com

Bruce D. Car

Discovery Toxicology, Bristol-Myers Squibb Company, Princeton, New Jersey 08543, USA

Key Words: Metabonomics • NMR spectroscopy • biomarker development • systems biology.

References

  • Beckwith-Hall, B.M., Holmes, E., Lindon, J.C., Gounarides, J., Vickers, A., Shapiro, M., and Nicholson, J.K. (2002). NMR-based metabonomic studies on the biochemical effects of commonly used drug carrier vehicles in the rat. Chem Res Toxicol 15, 1136—41.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Bollard, M.E., Holmes, E., Lindon, J.C., Mitchell, S.C., Branstetter, D., Zhang, W., and Nicholson, J.K. (2001). Investigations into biochemical changes due to diurnal variation and estrus cycle in female rats using high-resolution 1H-NMR spectroscopy of urine and pattern recognition. Anal Biochem 295, 194—202.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Espina, J.R., Shockcor, J.P., Herron, W.J., Car, B.D., Contel, N.R., Ciaccio, P.J., Lindon, J.C., Holmes, E., and Nicholson, J.K. (2001). Detection of in vivo biomarkers of phospholipidosis using NMR-based metabonomic approaches. Magn Reson Chem 36, 559—65.
  • Holmes, E., Bonner, F., and Nicholson, J.K. (1995). Comparative studies on the nephrotoxicity of 2-bromoethanamine hydrobromide in the Fischer 344 rat and the multimammate desert mouse (Mastomys natalensis). Arch Toxicol 70, 89—95.[Web of Science][Medline] [Order article via Infotrieve]
  • Holmes, E., Nicholls, A.W., Lindon, J.C., Connor, S.C., Connelly, J.C., Haselden, J.N., Damment, S.J.P., Spraul, M., Neidig, P., and Nicholson, J.K. (2000). Chemometric models for toxicity classification based on NMR spectra of biofluids. Chem Res Toxicol 13, 471—78.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Lenz, E.M., Bright, J., Wilson, I.D., Morgan, S.R., and Nash, A.F. (2003). A 1H NMR-based metabonomic study of urine and plasma samples obtained from healthy human subjects. J Pharm Biomed Anal 33, 1103—15.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Mortishire-Smith, R.J., Skiles, G.L., Lawrence, J.W., Spence, S., Nicholls, A.W., Johnson, B.A., and Nicholson, J.K. (2004). Use of metabonomics to identify impaired fatty acid metabolism as the mechanism of drug-induced toxicity. Chem Res Toxicol 17, 165—73.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Nicholls, A.Q., Mortishire-Smith, R.J., and Nicholson, J.K. (2003). NMR spectroscopic-based metabonomic studies of urinary metabolite variation in acclimatizing germ-free rats. Chem Res Toxicol 16, 1395—404.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Nicholson, J.K., Connelly, J., Lindon, J.C., and Holmes, E. (2002). Metabonomics: A platform for studying drug toxicity and gene function. Nature Rev Drug Disc 1, 153—61.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Nicholson, J.K., Lindon, J.C., and Holmes, E. (1999). Metabonomics: Understanding the metabolic responses of liver systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 29, 1181—9.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Robertson, D.G., Reily, M.D., Albassam, M., and Dethloff, L.A. (2001). Metabonomic assessment of vasculitis in rats. Cardiovasc Tox 1, 7—19.[CrossRef]
  • Robertson, D.G., Reily, M.D., Sigler, R.E., Wells, D.F., Paterson, D.A., and Braden, T.K. (2000). Metabonomics: evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants. Toxicol Sci 57, 326—37.[Abstract/Free Full Text]
  • Slim, R.M., Robertson, D.G., Albassam, M., Reily, M.D., Robosky, L., and Dethloff, L.A. (2002). Effect of dexamethasone on the metabonomics profile associated with phosphodiesterase inhibitor-induced vascular lesions in rats. Toxicol Appl Pharmacol 183, 108—16.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]

Toxicologic Pathology, Vol. 32, No. 2 suppl, 94-95 (2004)
DOI: 10.1080/01926230490462084


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
Toxicol SciHome page
W. G. E. J. Schoonen, C. P. A. M. Kloks, J.-P. H. T. M. Ploemen, M. J. Smit, P. Zandberg, G. J. Horbach, J.-R. Mellema, C. Thijssen-vanZuylen, A. C. Tas, J. H. J. van Nesselrooij, et al.
Uniform Procedure of 1H NMR Analysis of Rat Urine and Toxicometabonomics Part II: Comparison of NMR Profiles for Classification of Hepatotoxicity
Toxicol. Sci., July 1, 2007; 98(1): 286 - 297.
[Abstract] [Full Text] [PDF]


This Article
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Lehman-Mckeeman, L. D.
Right arrow Articles by Car, B. D.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Lehman-Mckeeman, L. D.
Right arrow Articles by Car, B. D.
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?