This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Lilbert, J. Articles by Mowat, V. Search for Related Content PubMed PubMed Citation Articles by Lilbert, J. Articles by Mowat, V. Social Bookmarking                         What's this?

Common Vascular Changes in the Jugular Vein of Saline Controls in Continuous Infusion Studies in the Beagle Dog

MDS Pharma Services, Les Oncins, 69210 Saint-Germain-Sur-L'Arbresle, France, juliette.lilbert{at}mdsps.com

Vasanthi Mowat

MDS Pharma Services, Les Oncins, 69210 Saint-Germain-Sur-L'Arbresle, France

This review was performed to assess the nature and incidence of procedure-related background changes in control dogs receiving saline by continuous infusion, and to compare them with data from a similar review previously done in Cynomolgus monkeys. Data were collected from 14 dog studies performed over an 8-year period (i.e., 86 animals in total). The review was restricted to lesions at the injection site, in the lungs and at the catheter's entry point. The most frequently seen changes were endothelial hyperplasia (67.4%) and intimal thickening at the injection site (80.2%) and interstitial pneumonitis in the lungs (52.6%), all seen at a higher incidence in dogs than in primates. Although incidences of thrombosis at the injection site were similar in both dogs (27.9%) and monkeys (34.1%), the incidences of thromboemboli and secondary infarction in the lungs were much higher in dogs. This suggests that dogs have a greater propensity to thrombus formation and fragmentation at the injection site. However the fact that the femoral vein is used in monkeys and the jugular vein in dogs may explain this difference. The larger diameter of the jugular vein in the dog with its greater turbulence of blood flow possibly predisposes to fragmentation and dispersal of thrombi.

Key Words: Dog • intravenous infusion • injection • vascular lesions • saline • primates • comparison.

References

• Burrows, C.F. (1973). Techniques and complications of intravenous and intraarterial catheterization in dogs and cats. J Amer Vet Med Asso 163, 1357—63.
• Dudrick, S.J., Vars, H.M., and Rhoads, J.E. (1966). Growth of puppies receiving all nutritional requirements by vein. Fortsch Parent Ernähung 2, 16—8.
• Evans, J.G., and Kerry, P.J. (2000). Common pathological findings in continuous infusion studies. In Handbook of Pre-Clinical Continuous Intravenous Infusion (G. Healing and D. Smith, eds.), pp. 253—64. Taylor & Francis, London.
• Hickling, K., and Smith, D. (2000). The contribution of vehicles, rates of administration and volumes to infusion studies. In Handbook of Pre-Clinical Continuous Intravenous Infusion (G. Healing and D. Smith, eds.), pp. 285— 97. Taylor & Francis, London.
• Jacobson, A. (2000). Equipment for continuous intravenous infusion. In Handbook of Pre-clinical Continuous Intravenous Infusion (G. Healing and D. Smith, eds.), pp. 299—325. Taylor & Francis, London.
• Lilbert, J., and Burnett, R. (2003). Main vascular changes seen in the saline controls of continuous infusion studies in the Cynomolgus monkey over an 8-year period. Toxicol Pathol 31, 273—80.[Abstract/Free Full Text]
• Mesfin, G.M., Higgins, M.J., Brown, W.P., and Rosnick, D. (1988). Cardiovascular complication of chronic characterization of the jugular vein in the dog. Vet Pathol 25, 492—502.[Abstract]
• Morton, D., Safron, J.A., Glosson, J., Rice, D.W., Wilson, D.M., and White, R.D. (1997). Histologic lesions associated with intravenous infusions of large volume of isotonic saline solution in rats for 30 days. Toxicol Pathol 25, 390—4.[Abstract/Free Full Text]
• Pickersgill, N. (2000). Jugular cannulation in the dog. In Handbook of Pre-clinical Continuous Intravenous Infusion (G. Handling and D. Smith, eds.), pp. 125—34. Taylor & Francis, London.
• Pickersgill, N., and Burnett, R. (2000). The non-ambulatory model in dog multidose infusion toxicity studies. In Handbook of Pre-clinical Continuous Intravenous Infusion (G. Handling and D. Smith, eds.), pp. 135—47. Taylor & Francis, London.
• Winocour, P.D., Cattaneo, M., Somers, D., Richardson, M., Kinlough-Rathbone, R.L., and Mustard, J.F. (1982). Platelet survival and thrombosis. Arteriosclerosis 2, 458—66.[Abstract/Free Full Text]

Toxicologic Pathology, Vol. 32, No. 6, 694-700 (2004)
DOI: 10.1080/01926230490524274


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Lilbert, J. Articles by Mowat, V. Search for Related Content PubMed PubMed Citation Articles by Lilbert, J. Articles by Mowat, V. Social Bookmarking                         What's this?