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DOI: 10.1080/01926230601059993
Overview of the Molecular Carcinogenesis of Mouse Lung Tumor Models of Human Lung CancerLaboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA Correspondence: Address correspondence to: Robert C. Sills, Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, MD B3-06, 111 Alexander Drive, Research Triangle Park, North Carolina 27709, USA; e-mail:sills{at}niehs.nih.gov Lung cancer is the leading cause of cancer death worldwide, and the need to develop better diagnostic techniques and therapies is urgent. Mouse models have been utilized for studying carcinogenesis of human lung cancers, and many of the major genetic alterations detected in human lung cancers have also been identified in mouse lung tumors. The importance of mouse models for understanding human lung carcinogenic processes and in developing early diagnostic techniques, preventive measures and therapies cannot be overstated. In this report, the major known molecular alterations in lung tumorigenesis of mice are reviewed and compared to those in humans.
Key Words: Lung tumor • oncogenes • tumor suppressor genes • K-ras • p53
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