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Malignant Myopericytoma-like Tumor in a Fischer Rat
Naofumi Takahashi*,
Toshinori Yoshida,
Yukiko Takeuchi,
Maki Kuwahara,
Nobuaki Nakashima,
Yuko Chiba,
and
Takanori Harada
* To whom correspondence should be addressed. E-mail: n.takahashi{at}iet.or.jp.
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Abstract |
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Myopericytoma is a perivascular tumor that has been recently described in humans, but not in laboratory rodents. The authors encountered an intra-abdominal tumor resembling human malignant myopericytoma in a Fischer rat. Grossly, the tumor was found as two brown-colored masses located in the mesentery of rectum. Microscopically, the tumor was composed of oval to spindle-shaped cells, which were arranged in sheets around numerous thin-walled branching vessels and partly showed a concentric perivascular growth pattern. Mitoses were frequently seen, and the tumor cells showed a local invasion. Immunohistochemically, the tumor cells were strongly positive for alpha-smooth muscle actin and weakly positive for vimentin and desmin. Ultrastructurally, the tumor cells had dendritic processes, actin-like thin filaments with dense bodies, basement membranes, hemidesmosomes, and micropinocytotic vesicles. These findings suggest that the most appropriate term for diagnosis of the present case could be a malignant myopericytoma.
First published on July 22, 2008, doi:10.1177/0192623308320804
Toxicologic Pathology 2008;36:738.
A more recent version of this article appeared on July 1, 2008
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