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Toxicologic Pathology
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0192623308327115v1
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Article

Comparison of Human to Macaque Uterosacral–Cardinal Ligament Complex and Its Relationship to Pelvic Organ Prolapse: A Monkey Model of Pelvic Organ Prolapse

Azin Shahryarinejad* and Michael David Vardy

* To whom correspondence should be addressed. E-mail: azin.shahryarinejad{at}mssm.edu.


  Abstract
The uterosacral–cardinal ligament complex is thought to be the critical structure responsible for uterine and apical vaginal support. It is ill defined and can be difficult to dissect in the cadaver lab and in the operating room. Even less information is available on the analogous structures in the monkey model. We present this report to bring together what little is known to aid in studying this model and pelvic organ prolapse (POP), and to point out the need for critical assessment of this hormone-responsive tissue in the process of drug development.

First published on October 27, 2008, doi:10.1177/0192623308327115

Toxicologic Pathology 2008;36:101S.

A more recent version of this article appeared on December 1, 2008

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