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Spontaneous and Chemically Induced Proliferative Lesions in Tg.AC Transgenic and p53-Heterozygous Mice

National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709

Norris D. Flagler

National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709

David E. Malarkey

North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina 27606

Peter C. Mann

Experimental Pathology Laboratories, Inc., Research Triangle Park, North Carolina 27709

Joseph K. Haseman

National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709

William Eastin

National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709

Recently, the use of selected genetically altered mouse models in the detection of carcinogens after short-term chemical exposures has been evaluated. Studies of several chemicals conducted by the National Toxicology Program in Tg.AC transgenic and heterozygous p53-deficient mice have been completed recently and represent a major contribution to this effort, as well as the largest accumulation to date of toxicologic pathology data in these 2 lines of mice. The purpose of this report is to describe the proliferative target organ effects observed in this set of studies, as well as to present the tumor profile in the control groups of this data set. These findings provide a comprehensive toxicologic assessment of these 2 genetically altered mouse strains, which are of emerging importance in toxicologic pathology.

Key Words: Mice • genetically altered • hazard identification • neoplasms • carcinogenicity

Toxicologic Pathology, Vol. 26, No. 4, 501-511 (1998)
DOI: 10.1177/019262339802600406


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