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Toxicologic Pathology
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Brief Communication

Fibro-osseous (FOL) and Degenerative Joint Lesions in Female Outbred NIH Black Swiss Mice

Lyn M. Wancket1, Deborah Devor-Henneman2 and Jerrold M. Ward3

1 College of Veterinary Medicine, University of Illinois, Urbana, Illinois, USA;
2 Department of Veterinary Biosciences, College of Veterinary Medicine, Ohio State University, Columbus, Ohio, USA and
3 Comparative Medicine Branch, NIAID, NIH, Bethesda, Maryland, USA

Correspondence: Address correspondence to: Lyn M. Wancket, Department of Veterinary Biosciences, College of Veterinary Medicine, Ohio State University, 1925 Coffey Road, Columbus, OH 43210–1291; e-mail: wancket.1{at}osu.edu.

A review of spontaneous bone and joint lesions in female aging NIH Black Swiss mice (Cr:NIH BL[S]) revealed a high incidence of fibro-osseous lesions (FOL; 89%) and degenerative joint lesions (90%). FOL was characterized by the replacement of bone marrow by fibrovascular tissue and was first seen at 59 weeks of age, most commonly in the nasal bone, femur, and tibia. FOL in female Black Swiss was often accompanied by reproductive-tract lesions, including ovarian atrophy and uterine cervical dysplasia with hydrometra. Mild degenerative femorotibial joint lesions developed by 59 weeks and progressed to full-thickness articular cartilage ulceration and osteophyte development by 75 weeks; joint inflammation was minimal. Although the underlying etiology of FOL remains unknown, an accurate assessment of FOL and degenerative joint disease as background lesions in this stock is necessary to interpret lesions in genetically engineered mice produced from this outbred line.

Key Words: Bone disease • bone marrow • mice • Swiss mice • degenerative joint disease

Abbreviations: Cr:NIH BL(S), NIH Black Swiss mice • FOL, fibro-osseous lesion • GEM, genetically engineered mice • NCI, National Cancer Institute • NIH, National Institutes of Health

This version was published on February 1, 2008

Toxicologic Pathology, Vol. 36, No. 2, 362-365 (2008)
DOI: 10.1177/0192623307312697
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