Mitchell N. Cayen and Hugh E. Black

Introduction
Toxicol Pathol 1995 23: 97. [PDF] [Request Permission]  

John Caldwell, Iain Gardner, and Nicola Swales

An Introduction to Drug Disposition: The Basic Principles of Absorption, Distribution, Metabolism, and Excretion
Toxicol Pathol 1995 23: 102-114. [Abstract] [PDF] [References] [Request Permission]  

Leslie Z. Benet and Parnian Zia-Amirhosseini

Basic Principles of Pharmacokinetics
Toxicol Pathol 1995 23: 115-123. [Abstract] [PDF] [References] [Request Permission]  

Shuet-Ling L. Chiu, A. Thompson, Stella H. Vincent, Raul F. Alvaro, Su-Er W. Huskey, Ralph A. Stearns, and Douglas J. Pettibone

The Role of Drug Metabolism in Drug Discovery: A Case Study in the Selection of an Oxytocin Receptor Antagonist for Development
Toxicol Pathol 1995 23: 124-130. [Abstract] [PDF] [References] [Request Permission]  

Gerald T. Miwa

Goals, Design, Timing, and Future Opportunities for Nonclinical Drug Metabolism Studies
Toxicol Pathol 1995 23: 131-135. [Abstract] [PDF] [References] [Request Permission]  

Samuel M. Cohen and Leon B. Ellwein

Relationship of DNA Adducts Derived from 2-Acetylaminofluorene to Cell Proliferation and the Induction of Rodent Liver and Bladder Tumors
Toxicol Pathol 1995 23: 136-142. [Abstract] [PDF] [References] [Request Permission]  

Peter G. Welling

Differences Between Pharmacokinetics and Toxicokinetics
Toxicol Pathol 1995 23: 143-147. [Abstract] [PDF] [References] [Request Permission]  

Mitchell N. Cayen

Considerations in the Design of Toxicokinetic Programs
Toxicol Pathol 1995 23: 148-157. [Abstract] [PDF] [References] [Request Permission]  

Vijay K. Batra

Toxicokinetics/Toxicodynamic Correlations: Goals, Methods, and Limitations
Toxicol Pathol 1995 23: 158-164. [Abstract] [PDF] [References] [Request Permission]  

Philip R. Mayer

Absorption, Metabolism, and Other Factors That Influence Drug Exposure in Toxicology Studies
Toxicol Pathol 1995 23: 165-169. [Abstract] [PDF] [References] [Request Permission]  

Andrew M. Dahlem, Sandra R. Allerheiligen, and Mary Jo Vodicnik

Concomitant Toxicokinetics: Techniques for and Interpretation of Exposure Data Obtained During the Conduct of Toxicology Studies
Toxicol Pathol 1995 23: 170-178. [Abstract] [PDF] [References] [Request Permission]  

Adrienne R. Takacs

Ancillary Approaches to Toxicokinetic Evaluations
Toxicol Pathol 1995 23: 179-186. [Abstract] [PDF] [References] [Request Permission]  

Alastair Monro and Joyce Mordenti

Expression of Exposure in Negative Carcinogenicity Studies: Dose/Body Weight, Dose/Body Surface Area, or Plasma Concentrations?
Toxicol Pathol 1995 23: 187-198. [Abstract] [PDF] [References] [Request Permission]  

Steven A. Wrighton, Barbara J. Ring, and Mark Vandenbranden

The Use of In Vitro Metabolism Techniques in the Planning and Interpretation of Drug Safety Studies
Toxicol Pathol 1995 23: 199-208. [Abstract] [PDF] [References] [Request Permission]  

Robert P. Clement

Preclinical Drug Metabolism Programs for Food-Producing Animals
Toxicol Pathol 1995 23: 209-216. [Abstract] [PDF] [References] [Request Permission]  

Mitchell N. Cayen

Toxicokinetic Challenges in the Pharmaceutical Industry
Toxicol Pathol 1995 23: 217-219. [PDF] [Request Permission]  

Joseph J. Degeorge

Food and Drug Administration Viewpoints on Toxicokinetics: The View from Review
Toxicol Pathol 1995 23: 220-225. [Abstract] [PDF] [References] [Request Permission]  

Jerrold M. Ward, Jerry F. Hardisty, James R. Hailey, and C. Spencer Streett

Peer Review in Toxicologic Pathology
Toxicol Pathol 1995 23: 226-234. [Abstract] [PDF] [References] [Request Permission]  

Benjamin F. Trump

News From the Editor
Toxicol Pathol 1995 23: 235. [PDF] [Request Permission]  

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