Corine Klingbeil and Di-Hwei Hsu

Pharmacology and Safety Assessment of Humanized Monoclonal Antibodies for Therapeutic Use
Toxicol Pathol 1999 27: 1-3. [Abstract] [PDF] [References]  

Anne M. Pilaro and Mercedes A. Serabian

Preclinical Development Strategies for Novel Gene Therapeutic Products
Toxicol Pathol 1999 27: 4-7. [Abstract] [PDF] [References]  

David K. Monteith and Arthur A. Levin

Synthetic Oligonucleotides: The Development of Antisense Therapeutics
Toxicol Pathol 1999 27: 8-13. [Abstract] [PDF] [References]  

Joyce Mordenti, Karen Thomsen, Vojtech Licko, Helen Chen, Y. Gloria Meng, and Napoleone Ferrara

Efficacy and Concentration-Response of Murine Anti-VEGF Monoclonal Antibody in Tumor-Bearing Mice and Extrapolation to Humans
Toxicol Pathol 1999 27: 14-21. [Abstract] [PDF] [References]  

Lauren E. Black, Alison M. Bendele, Ray A. Bendele, Philip M. Zack, and Marta Hamilton

Regulatory Decision Strategy for Entry of a Novel Biologic Therapeutic with a Clinically Unmonitorable Toxicity into Clinical Trials: Pre-IND Meetings and a Case Example
Toxicol Pathol 1999 27: 22-26. [Abstract] [PDF] [References]  

Mercedes A. Serabian and Anne M. Pilaro

Safety Assessment of Biotechnology-Derived Pharmaceuticals: ICH and Beyond
Toxicol Pathol 1999 27: 27-31. [Abstract] [PDF] [References]  

Kent A. Gossett, Padma K. Narayanan, Donna M. Williams, Elizabeth R. Gore, Danuta J. Herzyk, Timothy K. Hart, and Teresa S. Sellers

Flow Cytometry in the Preclinical Development of Biopharmaceuticals
Toxicol Pathol 1999 27: 32-37. [Abstract] [PDF] [References]  

Stuart Levin, Robert M. Friedman, Enriqueta Cortez, Jeremy Hribar, Mark Nicholas, Sally Schlessinger, Monique Fouant, and Nasir Khan

Lesions and Identification of Crystalline Precipitates of Glycoprotein IIb-IIIa Antagonists in the Rat Kidney
Toxicol Pathol 1999 27: 38-43. [Abstract] [PDF]  

J.K. Maurer and J.V. Jester

Use of In Vivo Confocal Microscopy to Understand the Pathology of Accidental Ocular Irritation
Toxicol Pathol 1999 27: 44-47. [Abstract] [PDF] [References]  

Nancy A. Gillett and Curtis M. Chan

Molecular Pathology in the Preclinical Development of Biopharmaceuticals
Toxicol Pathol 1999 27: 48-52. [Abstract] [PDF] [References]  

Raj K. Puri

Toxicologic Pathology of Cytokines, Cytokine Receptors, and Other Recombinant Human Proteins: Development of a Recombinant Interleukin-4-Pseudomonas Exotoxin for Therapy of Glioblastoma
Toxicol Pathol 1999 27: 53-57. [Abstract] [PDF] [References]  

Bruce D. Car, Vicki M. Eng, Jack M. Lipman, and Timothy D. Anderson

The Toxicology of Interleukin-12: A Review
Toxicol Pathol 1999 27: 58-63. [Abstract] [PDF] [References]  

Dimitry M. Danilenko

Preclinical and Early Clinical Development of Keratinocyte Growth Factor, an Epithelial- Specific Tissue Growth Factor
Toxicol Pathol 1999 27: 64-71. [Abstract] [PDF] [References]  

Joann C.L. Schuh and Philip J. Morrissey

Development of a Recombinant Growth Factor and Fusion Protein: Lessons from GM-CSF
Toxicol Pathol 1999 27: 72-77. [Abstract] [PDF] [References]  

Anne M. Ryan, Dorothy Bates Eppler, Kelly E. Hagler, Richard H. Bruner, Peter J. Thomford, Robert L. Hall, George M. Shopp, and Charles A. O'Neill

Preclinical Safety Evaluation of rhuMAbVEGF, an Antiangiogenic Humanized Monoclonal Antibody
Toxicol Pathol 1999 27: 78-86. [Abstract] [PDF] [References]  

H.G. Haggerty, W.A. Warner, C.R. Comereski, W.M. Peden, L.E. Mezza, B.D. Damle, C.B. Siegall, and T.J. Davidson

BR96 sFv-PE40 Immunotoxin: Nonclinical Safety Assessment
Toxicol Pathol 1999 27: 87-94. [Abstract] [PDF] [References]  

Scott P. Henry, Michael V. Templin, Nancy Gillett, Jennifer Rojko, and Arthur A. Levin

Correlation of Toxicity and Pharmacokinetic Properties of a Phosphorothioate Oligonucleotide Designed to Inhibit ICAM-1
Toxicol Pathol 1999 27: 95-100. [Abstract] [PDF] [References]  

Georgina M. Nemecek and Anthony D. Dayan

Safety Evaluation of Human Living Skin Equivalents
Toxicol Pathol 1999 27: 101-103. [Abstract] [PDF] [References]  

Carl L. Alden, John E. Sagartz, Peter F. Smith, Alan G. Wilson, Roderick T. Bunch, and Dale L. Morris

The Pathologist and Toxicologist in Pharmaceutical Product Discovery
Toxicol Pathol 1999 27: 104-106. [Abstract] [PDF] [References]  

Charles P. Rodi, Roderick T. Bunch, Sandra W. Curtiss, Larry D. Kier, Marc A. Cabonce, Julio C. Davila, Michael D. Mitchell, Carl L. Alden, and Dale L. Morris

Revolution through Genomics in Investigative and Discovery Toxicology
Toxicol Pathol 1999 27: 107-110. [Abstract] [PDF] [References]  

Daniel G. Rudmann and Stephen K. Durham

Utilization of Genetically Altered Animals in the Pharmaceutical Industry
Toxicol Pathol 1999 27: 111-114. [Abstract] [PDF] [References]  

Joann C.L. Schuh and Kimberly A. Harrington

Mechanisms of Disease and Injury: Utilization of Mutants, Monoclonals, and Molecular Methods
Toxicol Pathol 1999 27: 115-120. [Abstract] [PDF] [References]  

Lawrence H. Arp

Tumor Models: Assessing Toxicity in Efficacy Studies
Toxicol Pathol 1999 27: 121-122. [Abstract] [PDF] [References]  

Michael W. Leach, Natalie J. Davidson, Madeline M. Fort, Fiona Powrie, and Donna M. Rennick

The Role of IL-10 in Inflammatory Bowel Disease: "Of Mice and Men"
Toxicol Pathol 1999 27: 123-133. [Abstract] [PDF] [References]  

Alison Bendele, Jennifer Mccomb, TY Gould, Tracy Mcabee, Gina Sennello, Elizabeth Chlipala, and Michael Guy

Animal Models of Arthritis: Relevance to Human Disease
Toxicol Pathol 1999 27: 134-142. [Abstract] [PDF] [References]  

James R. Hartke

Preclinical Development of Agents for the Treatment of Osteoporosis
Toxicol Pathol 1999 27: 143-147. [Abstract] [PDF] [References]  

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