Prologue
Toxicol Pathol 2001 29: 1-4. [PDF]  

Gilbert S. Omenn

Assessment of Human Cancer Risk: Challenges for Alternative Approaches
Toxicol Pathol 2001 29: 5-12. [Abstract] [PDF] [References]  

Denise E. Robinson and James S. Macdonald

Background and Framework for ILSI's Collaborative Evaluation Program on Alternative Models for Carcinogenicity Assessment
Toxicol Pathol 2001 29: 13-19. [Abstract] [PDF] [References]  

James A. Popp

Criteria for the Evaluation of Studies in Transgenic Models
Toxicol Pathol 2001 29: 20-23. [Abstract] [PDF] [References]  

John French, Richard D. Storer, and Lawrence A. Donehower

The Nature of the Heterozygous Trp53 Knockout Model for Identifi cation of Mutagenic Carcinogens
Toxicol Pathol 2001 29: 24-29. [Abstract] [PDF] [References]  

Richard D. Storer, John E. French, Joseph Haseman, Gerald Hajian, Edmund K. Legrand, Gerald G. Long, Lori A. Mixson, Ricardo Ochoa, John E. Sagartz, and Keith A. Soper

p53 +/- Hemizygous Knockout Mouse: Overview of Available Data
Toxicol Pathol 2001 29: 30-50. [Abstract] [PDF] [References]  

Raymond W. Tennant, Stanley Stasiewicz, William C. Eastin, John H. Mennear, and Judson W. Spalding

The Tg.AC (v-Ha-ras) Transgenic Mouse: Nature of the Model
Toxicol Pathol 2001 29: 51-59. [Abstract] [PDF] [References]  

William C. Eastin, John H. Mennear, Ray W. Tennant, Ray E. Stoll, Dan G. Branstetter, John R. Bucher, Bruce Mccullough, Robert L. Binder, Judson W. Spalding, and Joel F. Mahler

Tg.AC Genetically Altered Mouse: Assay Working Group Overview of Available Data
Toxicol Pathol 2001 29: 60-80. [Abstract] [PDF] [References]  

Norikazu Tamaoki

The rasH2 Transgenic Mouse: Nature of the Model and Mechanistic Studies on Tumorigenesis
Toxicol Pathol 2001 29: 81-89. [Abstract] [PDF] [References]  

Toshimi Usui, Mamoru Mutai, Shigeru Hisada, Masaya Takoaka, Keith A. Soper, Bruce Mccullough, and Carl Alden

CB6F1-rasH2 Mouse: Overview of Available Data
Toxicol Pathol 2001 29: 90-108. [Abstract] [PDF] [References]  

Harry Van Steeg, Annemieke De Vries, Conny TH. M. Van Oostrom, Jan Van Benthem, Rudolf B. Beems, and Coen F. Van Kreijl

DNA Repair—Deficient Xpa and Xpa/p53+/- Knock-Out Mice: Nature of the Models
Toxicol Pathol 2001 29: 109-116. [Abstract] [PDF] [References]  

Coen F. Van Kreijl, Peter A. Mcanulty, Rudolf B. Beems, AN Vynckier, Harry Van Steeg, Ronny Fransson-Steen, Carl L. Alden, Roy Forster, Jan-Willem Van der Laan, and John Vandenberghe

Xpa and Xpa/p53+/- Knockout Mice: Overview of Available Data
Toxicol Pathol 2001 29: 117-127. [Abstract] [PDF] [References]  

R. Michael Mcclain, Douglas Keller, Dan Casciano, Peter Fu, James Macdonald, James Popp, and John Sagartz

Neonatal Mouse Model: Review of Methods and Results
Toxicol Pathol 2001 29: 128-137. [Abstract] [PDF] [References]  

R.J. Mauthe, D.P. Gibson, R.T. Bunch, and L. Custer

The Syrian Hamster Embryo (SHE) Cell Transformation Assay: Review of the Methods and Results
Toxicol Pathol 2001 29: 138-146. [Abstract] [PDF] [References]  

Sundaresan Venkatachalam, Stuart D. Tyner, Curtis R. Pickering, Scott Boley, Leslie Recio, John E. French, and Lawrence A. Donehower

Is p53 Haploinsufficient for Tumor Suppression? Implications for the p53+/- Mouse Model in Carcinogenicity Testing
Toxicol Pathol 2001 29: 147-154. [Abstract] [PDF] [References]  

Paul L. Carmichael, Jeremy J. Mills, Mathew Campbell, Maya Basu, and John Caldwell

Mechanisms of Hormonal Carcinogenesis in the p53+/- Hemizygous Knockout Mouse: Studies With Diethylstilbestrol
Toxicol Pathol 2001 29: 155-160. [Abstract] [PDF] [References]  

Noritaka Ariyoshi, Susumu Imaoka, Kazuo Nakayama, Yoshiki Takahashi, Ken-Ichi Fujita, Yoshihiko Funae, and Tetsuya Kamataki

Comparison of the Levels of Enzymes Involved in Drug Metabolism between Transgenic or Gene-knockout and the Parental Mice
Toxicol Pathol 2001 29: 161-172. [Abstract] [PDF] [References]  

Jay I. Goodman

A Perspective on Current and Future Uses of Alternative Models for Carcinogenicity Testing
Toxicol Pathol 2001 29: 173-176. [Abstract] [PDF] [References]  

John Ashby

Expectations for Transgenic Rodent Cancer Bioassay Models
Toxicol Pathol 2001 29: 177-182. [Abstract] [PDF] [References]  

Samuel M. Cohen

Alternative Models for Carcinogenicity Testing: Weight of Evidence Evaluations Across Models
Toxicol Pathol 2001 29: 183-190. [Abstract] [PDF] [References]  

Syril D. Pettit

Panel Discussion on the Application of Alternative Models to Cancer Risk Assessment
Toxicol Pathol 2001 29: 191-195. [Abstract] [PDF]  

Syril P. Pettit

Epilogue
Toxicol Pathol 2001 29: 196-197. [PDF]  

Appendix I: ILSI Alternatives Methods for Carcinogenicity Testing Workshop Poster Abstracts
Toxicol Pathol 2001 29: 198-322. [PDF]  

Appendix II: Rationale Statements for Selection of Compounds to be Tested in ILSI Alternatives to Carcinogenicity Testing Program
Toxicol Pathol 2001 29: 323-338. [PDF]  

Appendix III: Published Reference Lists for Several Alternative Models for Carcinogenicity Testing
Toxicol Pathol 2001 29: 339-351. [PDF]  

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