November 21, 2009

Sandra Viviana Fernandez and Jose Russo

Estrogen and Xenoestrogens in Breast Cancer
Toxicol Pathol first published on November 21, 2009 as doi:10.1177/0192623309354108
[Abstract] [OnlineFirst PDF]  

November 17, 2009

Le Cheng, Anirudh V. Ramesh, Andrea Flesken-Nikitin, Jinhyang Choi, and Alexander Yu. Nikitin

Mouse Models for Cancer Stem Cell Research
Toxicol Pathol first published on November 17, 2009 as doi:10.1177/0192623309354109
[Abstract] [OnlineFirst PDF]  

November 13, 2009

Gerald G. Long, Daniel Morton, Terry Peters, Brian Short, and Mikala Skydsgaard

Alternative Mouse Models for Carcinogenicity Assessment: Industry Use and Issues With Pathology Interpretation
Toxicol Pathol first published on November 13, 2009 as doi:10.1177/0192623309354107
[Abstract] [OnlineFirst PDF]  

November 11, 2009

Richard A. Westhouse

Safety Assessment Considerations and Strategies for Targeted Small Molecule Cancer Therapeutics in Drug Discovery
Toxicol Pathol first published on November 11, 2009 as doi:10.1177/0192623309354341
[Abstract] [OnlineFirst PDF]  

November 5, 2009

Richard D. Storer, Frank D. Sistare, M. Vijayaraj Reddy, and Joseph J. DeGeorge

An Industry Perspective on the Utility of Short-Term Carcinogenicity Testing in Transgenic Mice in Pharmaceutical Development
Toxicol Pathol first published on November 5, 2009 as doi:10.1177/0192623309351718
[Abstract] [OnlineFirst PDF]  

November 3, 2009

David Jacobson-Kram

Cancer Risk Assessment Approaches at the FDA/CDER: Is the Era of the 2-Year Bioassay Drawing to a Close?
Toxicol Pathol first published on November 3, 2009 as doi:10.1177/0192623309351892
[Abstract] [OnlineFirst PDF]  

November 2, 2009

John French, Bernard Leblanc, Gerald Long, Daniel Morton, Richard Storer, John Leighton, Jim Swenberg, and Hiroykuki Tsuda

Panel Discussion: Alternative Mouse Models for Carcinogenicity Assessment
Toxicol Pathol first published on November 2, 2009 as doi:10.1177/0192623309352091
[Abstract] [OnlineFirst PDF]  

October 30, 2009

Jacob Raber

Unintended Effects of Cranial Irradiation on Cognitive Function
Toxicol Pathol first published on October 30, 2009 as doi:10.1177/0192623309352003
[Abstract] [OnlineFirst PDF]  

October 26, 2009

John R. Senior

Unintended Hepatic Adverse Events Associated with Cancer Chemotherapy
Toxicol Pathol first published on October 26, 2009 as doi:10.1177/0192623309351719
[Abstract] [OnlineFirst PDF]  

October 23, 2009

Igor Mikaelian, Denise Coluccio, Gerard M. Hirkaler, John C. Downing, Erik Rasmussen, John Todd, Joel Estis, Quynh Anh Lu, and Rosemary Nicklaus

Assessment of the Toxicity of Hydralazine in the Rat Using an Ultrasensitive Flow-based Cardiac Troponin I Immunoassay
Toxicol Pathol first published on October 23, 2009 as doi:10.1177/0192623309351894
[Abstract] [OnlineFirst PDF]  

October 21, 2009

Mark J. Hoenerhoff, Hue Hua Hong, Tai-Vu Ton, Stephanie A. Lahousse, and Robert C. Sills

A Review of the Molecular Mechanisms of Chemically Induced Neoplasia in Rat and Mouse Models in National Toxicology Program Bioassays and Their Relevance to Human Cancer
Toxicol Pathol first published on October 21, 2009 as doi:10.1177/0192623309351726
[Abstract] [OnlineFirst PDF]  

October 20, 2009

Jerrold M. Ward

The Roles of the Toxicologic Pathologist in Cancer Research
Toxicol Pathol first published on October 20, 2009 as doi:10.1177/0192623309351727
[Abstract] [OnlineFirst PDF]  

Katsuhiko Yoshizawa, Amy E. Brix, Donald M. Sells, Micheal P. Jokinen, Michael Wyde, Denis P. Orzech, Grace E. Kissling, Nigel J. Walker, and Abraham Nyska

Reproductive Lesions in Female Harlan Sprague-Dawley Rats Following two-Year Oral Treatment With Dioxin and Dioxin-Like Compounds
Toxicol Pathol first published on October 20, 2009 as doi:10.1177/0192623309351721
[Abstract] [OnlineFirst PDF]  

October 19, 2009

Kathryn Bailey, Yajuan Xia, William O. Ward, Geremy Knapp, Jinyao Mo, Judy L. Mumford, Russell D. Owen, and Sheau-Fung Thai

Global Gene Expression Profiling of Hyperkeratotic Skin Lesions from Inner Mongolians Chronically Exposed to Arsenic
Toxicol Pathol first published on October 19, 2009 as doi:10.1177/0192623309351725
[Abstract] [OnlineFirst PDF]  

Deacqunita L. Harris, Mary K. Washington, Darryl B. Hood, L. Jackson Roberts II, and Aramandla Ramesh

Dietary Fat-Influenced Development of Colon Neoplasia in Apc^Min Mouse Exposed to Benzo(a)pyrene
Toxicol Pathol first published on October 19, 2009 as doi:10.1177/0192623309351722
[Abstract] [OnlineFirst PDF]  

Paula-Anahi Arias-Loza, Melanie Muehlfelder, Susan A. Elmore, Robert Maronpot, Kai Hu, Hartmut Blode, Christa Hegele-Hartung, Karl Heinrich Fritzemeier, Georg Ertl, and Theo Pelzer

Differential Effects of 17B -Estradiol and of Synthetic Progestins on Aldosterone-Salt Induced Kidney Disease
Toxicol Pathol first published on October 19, 2009 as doi:10.1177/0192623309350475
[Abstract] [OnlineFirst PDF]  

October 15, 2009

Min Wei, Al-Salmy Hamoud, Takashi Yamaguchi, Anna Kakehashi, Keiichirou Morimura, Kenichiro Doi, Masahiko Kushida, Mitsuaki Kitano, Hideki Wanibuchi, and Shoji Fukushima MD, PhD

Potassium Bromate Enhances N-Ethyl-N-Hydroxyethylnitrosamine-Induced Kidney Carcinogenesis Only at High Doses in Wistar Rats: Indication of the Existence of an Enhancement Threshold
Toxicol Pathol first published on October 15, 2009 as doi:10.1177/0192623309351720
[Abstract] [OnlineFirst PDF]  

Mark E. Cartwright DVM, PhD, Janet Petruska, Joseph Arezzo, Doyle Frank, Mona Litwak, Richard E. Morrissey, James MacDonald, and Thomas E. Davis

Phospholipidosis in Neurons Caused by Posaconazole, without Evidence for Functional Neurologic Effects.
Toxicol Pathol first published on October 15, 2009 as doi:10.1177/0192623309348521
[Abstract] [OnlineFirst PDF]  

October 9, 2009

Brad Bolon, Ricardo Ochoa, and Peter Mann

STP Debate on the Desirability of an International Mechanism for Recognizing Qualified Toxicologic Pathologists
Toxicol Pathol first published on October 9, 2009 as doi:10.1177/0192623309350476
[Abstract] [OnlineFirst PDF]  

October 5, 2009

Gail Pearse, Anne Pietersma, Jo Cunliffe, John R. Foster, John Turton, Nicola Derbyshire, and Kevin J. Randall

Time-course Study of the Immunotoxic Effects of the Anticancer Drug Chlorambucil in the Rat
Toxicol Pathol first published on October 5, 2009 as doi:10.1177/0192623309347907
[Abstract] [OnlineFirst PDF]  

October 2, 2009

Kun-Chao Chen, Chen-Wei Liao, Fen-Pang Cheng, Chi-Chung Chou, Shih-Chieh Chang, Jhaol-Huei Wu, Jyh-Myng Zen, Yng-Tay Chen, and Jiunn-Wang Liao

Evaluation of Subchronic Toxicity of Pet Food Contaminated With Melamine and Cyanuric Acid in Rats
Toxicol Pathol first published on October 2, 2009 as doi:10.1177/0192623309347910
[Abstract] [OnlineFirst PDF]  

Russell Westwood, Robert C. Scott, Rebecca L. Somers, Michelle Coulson, and Rose A. Maciewicz

Characterisation of Fibrodysplasia in the dog Following Inhibition of Metalloproteinases
Toxicol Pathol first published on October 2, 2009 as doi:10.1177/0192623309347909
[Abstract] [OnlineFirst PDF]  

September 21, 2009

Yuval Ramot, Shmulik Ben Eliahu, Leonid Kagan, Nathan Ezov, and Abraham Nyska

Subcutaneous and Intraperitoneal Lipogranulomas Following Subcutaneous Injection of Olive Oil in Sprague-Dawley Rats
Toxicol Pathol first published on September 21, 2009 as doi:10.1177/0192623309347911
[Abstract] [OnlineFirst PDF]  

Abraham Nyska DVM, Michael Cunningham, Michael Snell, David Malarkey, D. Sutton, and June Dunnick

The Pivotal Role of Electron Microscopic Evaluation in Investigation of the Cardiotoxicity of bis(2-chloroethoxy)methane in Rats and Mice
Toxicol Pathol first published on September 21, 2009 as doi:10.1177/0192623309347908
[Abstract] [OnlineFirst PDF]